DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_444414.2	Gene:	Ugt2a1 / 94215	MGIID:	2149905	Length:	528	Species:	Mus musculus

Alignment Length:	544	Identity:	139/544 - (25%)
Similarity:	258/544 - (47%)	Gaps:	45/544 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITV-----LKPVVNHK 68
            ||.:..|.:||...|.|:|  ...:..||.:........|..:.|||||:..     :.|.....
Mouse     6 LLCSLQISLLGMSLGGNVL--IWPMEGSHWLNVKIIIDELLRKEHNVTVLVASGALFITPSSISP 68

  Fly    69 NIT--VIMVPLTKE--ESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMA-----GALKD 124
            ::|  :..||..||  ||......:..:....:.:.|.:..:.|.::...|..::     |.||:
Mouse    69 SLTFEIYPVPFGKEKIESVIKDFVLTWLENRPSPSTIWTFYKEMAKVIEEFHLVSRGICDGVLKN 133

  Fly   125 DRVRDLYLNRDNKFDLVLSGYFMNVYQLG--FAKKVKAPVIVVATMPPNQLLNPLIGN-PLEIAY 186
            :::....  :..||:::||.   .|:..|  .|.|:..|.|......|...:....|. |...:|
Mouse   134 EKLMSKL--QKEKFEVLLSD---PVFPCGDIVALKLGIPFIYSLRFSPASTVEKHCGKVPFPPSY 193

  Fly   187 VPSI-SDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKR---LYKELFGDDPNMPEYSELV 247
            ||:| |:..::   |||..|:..:.|   :.:.|::.:...|:   .|.:..|....:   .|.:
Mouse   194 VPAILSELTDQ---MSFTDRVRNFIS---YRMQDYMFETLWKQWDSYYTKALGRPTTL---CETM 249

  Fly   248 KNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATD-GAILLSLGSNV 311
            ....:....::...|.| ||.:|....:||:..|.. .|||:.|.||:..:.: |.::.||||.|
Mouse   250 GKAEIWLMRTYWDFEFP-RPYLPNFEFVGGLHCKPA-KPLPKEMEEFVQTSGEHGIVVFSLGSMV 312

  Fly   312 KGSHINPDTVVKMFNVLSKLKQRVIWKWE-DLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINH 375
            |  ::..:....:.:.|:::.|:|:|::: .:..|.|.:..:|  .|:||:|:|.||..:.||.|
Mouse   313 K--NLTDEKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLF--DWIPQNDLLGHPKTRAFITH 373

  Fly   376 AGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYF 440
            .|..||.||.|||.||:.:|:|.|||.|...|..:|..:..::.::.......|:..:::.|.|.
Mouse   374 GGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDLLNALRTVINEPSYK 438

  Fly   441 DKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVIL 505
            :.....|.::.|:|:...:..::|.|:|:||.||.||:.....:|:...:::|:...:...:...
Mouse   439 ENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLACVASA 503

  Fly   506 VLLLKLLLQFIYRKIFAKPKKEKK 529
            :||:.....||::|:....||:|:
Mouse   504 ILLVAKCCLFIFQKVGKTGKKKKR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	130/503 (26%)
Ugt2a1	NP_444414.2	UDPGT	21..516	CDD:278624	129/516 (25%)
Ugt2a1	NP_444414.2	egt	<267..487	CDD:223071	70/224 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840