DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	152/561 - (27%)
Similarity:	252/561 - (44%)	Gaps:	83/561 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKNITVI 73
            |||..:.|...|..|..::   ..:..||.:......:.|.::||.|   |||:|     :.:|.
  Rat    10 LLLQISFCFKSGNCGKVLV---WPMEYSHWMNIKIILEELVQKGHEV---TVLRP-----SASVF 63

  Fly    74 MVPLTKEESQQMSDTI-GAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRD------LY 131
            :.|  ||.|.....|. .:.|..|              :|..|.:.......:..||      ||
  Rat    64 LDP--KETSDLKFVTFPTSFSSHD--------------LENFFTRFVNVWTYELPRDTCLSYFLY 112

  Fly   132 LN---------------------------RDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMP 169
            |.                           :::|||:|.|.......:| .|:.::.|.:......
  Rat   113 LQDTIDEYSDYCLTVCKEAVSNKQFMTKLQESKFDVVFSDAIGPCGEL-IAELLQIPFLYSLRFS 176

  Fly   170 PNQLLNPLIGNPL-EIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSK--RLYK 231
            |...:...||..| ..:|||.|...: .|: |:|.:|:.......:|. |.|.|.|..|  ..|.
  Rat   177 PGYTIEKYIGGVLFPPSYVPMIFSGL-AGQ-MTFIERVHNMICMLYFD-FWFQTFREKKWDPFYS 238

  Fly   232 ELFGDDPNMPEYSELVKNTSLIFFASHAPSE--GPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEF 294
            :..|....:   :|::....:....|:...|  .||.|||.   .|||:..|.. .|||:::.:|
  Rat   239 KTLGRPTTL---AEIMGKAEMWLIRSYWDLEFPHPISPNVD---YIGGLHCKPA-KPLPKDIEDF 296

  Fly   295 LGNATD-GAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWL 358
            :.::.: |.::.||||.|:........::..  .|:::.|:|:|:: |.:|.|....|....|||
  Rat   297 VQSSGEHGVVVFSLGSMVRNMTEEKANIIAW--ALAQIPQKVLWRF-DGKKPPTLGPNTRLYKWL 358

  Fly   359 PQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEE 423
            ||:|:|.||..|.|:.|.|..||.||.:||.||:.:|:||:|..|...||.:|..:..:..::.:
  Rat   359 PQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSK 423

  Fly   424 QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIA 488
            .....|:.|:::||.|.......|:::.|:|....:..::|.|:|:||.||.||:|...::.:..
  Rat   424 SDMLNALEEVINNPFYKKNAMWLSTIHHDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQ 488

  Fly   489 ANNIDIYA-LIAVVLVILVLLLKLLLQFIYRKIFAKPKKEK 528
            .:::|:.. |:..|.|.:||.||..| |:||....|.||.|
  Rat   489 YHSLDVIGFLLTCVAVTVVLALKCFL-FVYRFFVKKEKKTK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	136/520 (26%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	145/544 (27%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	74/225 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840