Protein Alignment Ugt37A2 and UGT2A3

DIOPT Version :9

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 139/574 - (24%)
• Similarity: 251/574 - (43%)
• Gaps: 95/574 - (16%)

  Fly     4 KSGIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAE----RGHNVTVITVLKP- 63
            ||.:..||....||  ||.....:.|: ....||.:    ..||:.|    |||.|||:|..||
Human     5 KSALVFLLLQLFCV--GCGFCGKVLVW-PCDMSHWL----NVKVILEELIVRGHEVTVLTHSKPS 62

  Fly    64 VVNHK-----NITVIMVPLTKEESQQMSDTIGAMSKTDNSNMI--LSMLRMMGQMEFMFDKMAGA 121
            :::::     ...|:.:|..:.|..::...:..       |::  ||..:.:.::...|.::.|.
Human    63 LIDYRKPSALKFEVVHMPQDRTEENEIFVDLAL-------NVLPGLSTWQSVIKLNDFFVEIRGT 120

  Fly   122 LKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAP----VIVVATMPPNQLLNPLIGNPL 182
            ||                ::...:   :|.....||::..    :::...:|...|:..|:..|.
Human   121 LK----------------MMCESF---IYNQTLMKKLQETNYDVMLIDPVIPCGDLMAELLAVPF 166

  Fly   183 EIAYVPSISDSVEKGKG-------------------MSFRQRLAGYSSSFFFGIFDFVTQRRSKR 228
            .:....|:..::|:..|                   |:|.:|:   .:|....:|.|..|.....
Human   167 VLTLRISVGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLERV---KNSMLSVLFHFWIQDYDYH 228

  Fly   229 LYKELFGDDPNMP-EYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLP---- 288
            .::|.:......| ...|.|....:....::...|.| :|..|....:||:..|.. ..||
Human   229 FWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFP-QPYQPNFEFVGGLHCKPA-KALPKINF 291

  Fly   289 --QNMAEFL-GNATDGAILLSLGS---NVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLE-KTP 346
              |.|..|: .:..||.::.||||   ||.....|     .:.:.|:::.|:|:|:::..: .|.
Human   292 YLQEMENFVQSSGEDGIVVFSLGSLFQNVTEEKAN-----IIASALAQIPQKVLWRYKGKKPSTL 351

  Fly   347 GKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQG 411
            |.:..::  .|:||:|:|.||..|.||.|.|..||.||.|||.||:.:|:||||..|...|..:|
Human   352 GANTRLY--DWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKG 414

  Fly   412 FGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAH 476
            ..:..:..::..:....|:..::::..|.:.....|.::.|:|:...:..::|.|:|:||.||.|
Human   415 AAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKH 479

  Fly   477 LQSPLVHMSFIAANNIDIYA-LIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            |:|....:::....:||:.. |:|.|...:.|..|..| |..:| |.|.:|.:|
Human   480 LRSAAHDLTWFQHYSIDVIGFLLACVATAIFLFTKCFL-FSCQK-FNKTRKIEK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	123/528 (23%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	129/548 (24%)
		egt	<267..498	CDD:223071	71/238 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840