DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt1b4

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001166239.2	Gene:	ugt1b4 / 795050	ZFINID:	ZDB-GENE-080227-13	Length:	533	Species:	Danio rerio

Alignment Length:	574	Identity:	145/574 - (25%)
Similarity:	261/574 - (45%)	Gaps:	103/574 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LATAICVLGGCHGANILGVFTSLSPSH----LIIQM---------STAKVLAERGHNVTVITVLK 62
            |...||::.|...:.::....|.:.|.    |::.|         :.|:.:..|||  |||.|:.
Zfish     7 LGVIICLVVGVVCSAVVDQKLSRNSSWTGKLLVVPMDGSHWTGVKAVAEEMGRRGH--TVIVVIP 69

  Fly    63 PV----------------VNHKN--ITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMG 109
            .:                |.:|.  |..|||    |...:::.:..::.||     :.|::...|
Zfish    70 EISMRLGPGKHYITKKFPVQYKQDLINQIMV----EHVNEVAASEQSLLKT-----VTSIMYRFG 125

  Fly   110 QMEFMFDKMAGALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVV--------- 165
            ::...|...:.:|..::....:| ||..||.||:...|.:..: .|..:..|.:.:
Zfish   126 KIIDHFISTSESLFQEQELIEFL-RDQNFDAVLTNPAMPMGAI-LAYNLSVPAVYMLRGIMCESK 188

  Fly   166 ATMPPNQLLNPLIGNPLEIAYVP----SISDSVEKGKGMSFRQRLAGYSSS--------FFFGIF 218
            ||..||.        |   :|:|    .|||.      |:|.:|:.....|        ...|.|
Zfish   189 ATACPNP--------P---SYIPRFFTQISDR------MTFSERVINTLVSLLEPLMCRLMLGSF 236

  Fly   219 DFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDT 283
            :.:|   ||.|::::        ..:|::...::.........|.| :|.:|..|.||||.. :.
Zfish   237 EEMT---SKFLHRDV--------SITEILSTAAVWLMRYDFTLEFP-KPLMPNMITIGGINC-EV 288

  Fly   284 PDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKW--EDLEKT 345
            .:||.:.:.||: |:...|.::.||||.|  |.:..:.....|...|.:.|||:|::  |.....
Zfish   289 KNPLTKEVEEFVNGSGEHGIVVFSLGSLV--SSMPKEKADIFFKAFSMIPQRVLWRYTGEIPNNV 351

  Fly   346 PGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQ 410
            |   :|:...|||||:|:|.||..:.||.|.|..||.|...||.||:.||:||||..|...:..:
Zfish   352 P---ENVKLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICHGVPMVMLPLFGDQADNVHRVATR 413

  Fly   411 GFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAA 475
            |.|:..|:..:..:...:|:..:::|..|..|:...|:::.|||:...:..::|||:|:||.||.
Zfish   414 GVGVILSIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGAD 478

  Fly   476 HLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            ||:.....::::..:::|:...:.::::|:.|.:.......:|:...|.:|.|:
Zfish   479 HLRPAAHELNWLQYHSLDVIGFMLLIVLIVTLAMLKCCSLCWRRCCRKTQKRKE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	138/533 (26%)
ugt1b4	NP_001166239.2	UDPGT	35..529	CDD:278624	137/541 (25%)
ugt1b4	NP_001166239.2	egt	<273..512	CDD:223071	79/244 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930