DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt2b6

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170806.2	Gene:	ugt2b6 / 792506	ZFINID:	ZDB-GENE-100402-4	Length:	527	Species:	Danio rerio

Alignment Length:	552	Identity:	153/552 - (27%)
Similarity:	259/552 - (46%)	Gaps:	83/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVIT-----VLKPVVNHK------NITV 72
            |.|  .|:|..||  ..||.|......:.|.:|||:|||:.     .:|...:.:      |:::
Zfish    17 GEC--GNVLVWFT--EGSHWINMKIVLETLIDRGHDVTVLVPDASLFMKANASDRFSYQPFNVSM 77

  Fly    73 IMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEF--MFDKM---------------AG 120
                    :.|:|        |......:...|..|.|:.|  |..|:               .|
Zfish    78 --------DEQEM--------KVFIEEFLYFSLYEMDQLNFFQMQSKVYEFTSKLQDMSISYCDG 126

  Fly   121 ALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLG--FAKKVKAPVIVVATMPPNQLLNPLIGN-PL 182
            .||...:.|..  |.:|||:|.|.   .:||..  .|:::..|::.............:.|. |.
Zfish   127 VLKSPGLLDKL--RKHKFDVVFSD---PIYQCSDIVAEELNVPLVYTFRFSLAHAAERMCGQIPA 186

  Fly   183 EIAYVP-SISDSVEKGKGMSFRQRLAGYSSSFF-----FGIFDFVTQRRSKRLYKELFGDDPNMP 241
            ..:||| ::|...:|   |||.:|:  |:..|:     |.||.:   ::....|.|.||   ...
Zfish   187 PPSYVPGAMSKLTDK---MSFTERI--YNMLFYLSQDAFAIFAW---KKIDNYYTEYFG---RPT 240

  Fly   242 EYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTP-DPLPQNMAEFL-GNATDGAIL 304
            .|.|::....:....::...|.| ||.||....|||:..  || .|||::|.||: .:..||.::
Zfish   241 SYCEMMGRADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC--TPAKPLPKDMEEFVQSSGEDGIVV 302

  Fly   305 LSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNI 369
            .:|||.|  ..:..:...::.:.|:::.|:|:|::.. ||.....:|....||:||:|:|.||..
Zfish   303 FTLGSLV--GKVPKEISNRIASALAQIPQKVLWRYGG-EKPDTLGENTRIYKWIPQNDLLGHPKT 364

  Fly   370 KLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFG-LTQSLLSLEEQPFKEAILEI 433
            :.||.|.|..|:.||.|||.||:.:|:|||||.|...|..:|.. :..|:.|::.|...:.:..:
Zfish   365 RAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKLNTV 429

  Fly   434 LSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALI 498
            :::|.|.:.....|.::.||||...:..::|.|:|:|:.||.||:....::::...:.:|::|.:
Zfish   430 INDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAFL 494

  Fly   499 AVVL-VILVLLLKLLLQFIYRKIFAKPKKEKK 529
            ..|| ::|.:..|:...||.|..|...:|.||
Zfish   495 TTVLTLVLYICFKMAKFFIMRCCFRSKRKSKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	140/510 (27%)
ugt2b6	NP_001170806.2	UDPGT	20..523	CDD:278624	148/542 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930