DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	515	Identity:	135/515 - (26%)
Similarity:	232/515 - (45%)	Gaps:	41/515 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SHLIIQMSTAKVLAERGHNVTVIT-VLKPVVNHK-----NITVIMVPLTKEESQ-QMSDTIGAMS 93
            ||........:.|.::.|:|||:. ...|.|.|.     ...|..|.:.|||:. .|.|.|...:
Zfish    31 SHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQKERFEYHVFKVNMEKEEADAAMRDMIHLFT 95

  Fly    94 KTDNSN--------MILSMLRMMGQMEF--MFDKMAGALKDDRVRDLYLNRDNKFDLVLSGYFMN 148
            ....:.        .::|.....|.:.|  :||  .|.||        ..||:.:|::.|...|.
Zfish    96 NDTAAKYEGEFVMWKVMSKFVEFGDVYFRGLFD--VGLLK--------TLRDSNYDVLFSDPMMP 150

  Fly   149 VYQLGFAKKVKAPVIVVATMPPNQLLNPLIGN-PLEIAYVPSISDSVEKGKGMSFRQRLAGYSSS 212
            ...| .|:|:..|.::............|.|. |...:|||:::.:......|||.:|:......
Zfish   151 FSDL-MAQKLNIPQVISMRATFAYAAERLCGQMPAPPSYVPAVALTDHLTDRMSFMERVENMLLY 214

  Fly   213 FFFGI-FDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIG 276
            ....| |..|........|.|:.|....|   .|.:....:....::...|.| ||..|....:|
Zfish   215 IVHSIAFPLVATFTFDGYYSEILGKPTTM---CETMGKVDICLIRTYWDFEYP-RPFPPNFKFVG 275

  Fly   277 GIQVKDTPDPLPQNMAEFLGNATD-GAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWE 340
            |:..|.. .||.:.:.||:.::.| |.::.||||.:|  ::..:....:...|.::.|:|:|::.
Zfish   276 GLHCKPA-KPLSKELEEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYS 337

  Fly   341 DLEKTPGK-SDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNA 404
            .  |||.. :.|.....|:||:|:|.||..|.||.|.|..|:.||.|||.||:.||:|||||.|.
Zfish   338 G--KTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNL 400

  Fly   405 DVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVI 469
            ..:..:|..:...:.::..:...:|:..:::||.|.:.:...|.::.|:||...:..:||.|:|:
Zfish   401 LHIKTKGAAVVLDIHTMGSKDLVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVM 465

  Fly   470 RHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            |:.||.||:.....:|:...:.:|:.|.:..:..::..|......|::|:...|.:.|:|
Zfish   466 RNKGAKHLRVQAHELSWYQYHCLDVAAFLLSITALITFLWVKACCFLFRRCVRKTRPERK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	127/474 (27%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	132/507 (26%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	74/241 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840