DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	555	Identity:	149/555 - (26%)
Similarity:	255/555 - (45%)	Gaps:	76/555 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLATAICVLGG-CHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKNIT-- 71
            |..|.|.:.|. |.|..||  ...|..||.:......|.|..:||.|.||.........:|.|
Zfish    34 LWTTVITIFGSLCDGGKIL--VAPLEGSHWVNMDILIKALHGQGHTVDVIRNANSWFIKENSTYY 96

  Fly    72 -VIMVPLTKEESQQM-SDTIGAMSKTD-NSNMILSMLRMMGQM--------EFMFDKMAGALKDD 125
             .|.:|.||...::. :|.:..|.|.: .....||::|:...:        |.:...:...|..:
Zfish    97 DTITIPNTKGWDEEFAADFVYKMIKYEKEKGSWLSIVRLYLNVFDAVKKTHEMVCQLITNILDSE 161

  Fly   126 RVRDLYLNRDNKFDLVLSGYFMNVYQLG--FAKKVKAPVIV-------------VATMPPNQLLN 175
            .:  |.:..:.::||:|:.   .|:..|  .|.|:|.|::.             :|..|
Zfish   162 EI--LKMLNEKQYDLMLTD---PVWGTGIILAHKLKLPMVYNVRWTTTGEGHFDIAPSP------ 215

  Fly   176 PLIGNPLEIAYVPSISDSVEKGKG----MSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKEL--- 233
                    ::|:|.      .|.|    |||.|||..|   ||:.:.|......:.:.|:.:
Zfish   216 --------MSYIPI------TGSGNTDRMSFFQRLKNY---FFYLLLDLQLSHFNVKQYQAICDK 263

  Fly   234 -FGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGN 297
             |....|   :.||::...|.........|.| ||.:|..|.|||.|.... .|||.::.:|:.:
Zfish   264 YFTSRVN---FHELLQGADLWLMRVDFVFEFP-RPTMPNIIYIGGFQCPPA-KPLPHDLEDFMQS 323

  Fly   298 ATD-GAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQD 361
            :.| |.|::||||.:  .::..:...::....::|.|:|||::.. :|....|:|.....|:||.
Zfish   324 SGDHGVIVMSLGSLI--GNLPENVTAEIAAAFARLPQKVIWRYTG-KKPSTLSNNTLMVDWMPQK 385

  Fly   362 DILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPF 426
            |:|.||..|:||:|.|..|:.||.|||.|::.:|.|.||..|...:..:|.....|:..|.|...
Zfish   386 DLLGHPKTKVFISHGGTNGVLEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKLLSIADLGENTL 450

  Fly   427 KEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANN 491
            ..||.|:::.|.|...:...|.|::|:|:...:|.|:|.|:|:||.|||||::....|.:.:.::
Zfish   451 HAAIQEVINEPSYRLNMHKLSHLHKDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHS 515

  Fly   492 IDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKK 526
            :|:...:..|::||...:.:.::::..|..::.:|
Zfish   516 VDVVVTLFAVVLILTYCIFVTVRYLCVKCCSQKRK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	143/517 (28%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	143/540 (26%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	81/244 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840