DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and UGT8

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001121646.2	Gene:	UGT8 / 7368	HGNCID:	12555	Length:	541	Species:	Homo sapiens

Alignment Length:	538	Identity:	147/538 - (27%)
Similarity:	255/538 - (47%)	Gaps:	67/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHN-VTVITVLKPVVNHKNIT 71
            ::||.:|:   |....|.|:.|...:..||:.|..:.|..|.||||: |.:::..:.:....:.:
Human     8 FILLWSAV---GIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYS 69

  Fly    72 VIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLR--MMGQMEF--MFDKMAGALKDDRVRDLYL 132
            :...|             |..:.|.:...:.|.:|  ..|::..  :||.:....|:   .||.:
Human    70 LQRYP-------------GIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKN---CDLMV 118

  Fly   133 N--------RDNKFDLVL------SGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLE 183
            .        :..||||:|      .| |:..:.||    ||..|.......|.:     :|.|..
Human   119 GNHALIQGLKKEKFDLLLVDPNDMCG-FVIAHLLG----VKYAVFSTGLWYPAE-----VGAPAP 173

  Fly   184 IAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYS--EL 246
            :||||..:..:.....:..|.:..|.......|:...|..:     |:.:......:||.|  :|
Human   174 LAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPK-----YERIMQKYNLLPEKSMYDL 233

  Fly   247 VKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATD-GAILLSLGSN 310
            |..:||....:....|.| ||.:|..:.:|||..|.. .|||:::..::..|.: |.:|:|.|:.
Human   234 VHGSSLWMLCTDVALEFP-RPTLPNVVYVGGILTKPA-SPLPEDLQRWVNGANEHGFVLVSFGAG 296

  Fly   311 VKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINH 375
            ||  :::.|...|:...|.:|.|:|||::.. .|.....:|....:||||:|:|.|..||.|::|
Human   297 VK--YLSEDIANKLAGALGRLPQKVIWRFSG-PKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSH 358

  Fly   376 AGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVK---QGFGLTQSLLSLEEQPFKEAILEILSNP 437
            .|...|.|..|||.|::.:|:|||   :.|.|.:   :|.|:.....::.|:...||::::::||
Human   359 GGLNSIFETIYHGVPVVGIPLFGD---HYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNP 420

  Fly   438 QYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVL 502
            .|..:....|.:::|:|.......|||.:|:|||:||.||::.:..:||.....:||..::.:..
Human   421 SYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGA 485

  Fly   503 VILVLLLKLLLQFIYRKI 520
            .:|..||..:.:||||||
Human   486 ALLYFLLSWVTKFIYRKI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	136/506 (27%)
UGT8	NP_001121646.2	Glycosyltransferase_GTB-type	21..502	CDD:415824	140/519 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150684
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840