Protein Alignment Ugt37A2 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 144/542 - (26%)
• Similarity: 253/542 - (46%)
• Gaps: 94/542 - (17%)

  Fly    36 SHLIIQMSTAKVLAERGHNVTVIT-VLKPVVNHKNITVIMV-----PLTK---EES--QQMSDTI 89
            ||.|...:..:.|.:|||.|||:| ....:||....:.|.:     .|||   |:|  :.:...|
Human    34 SHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWI 98

  Fly    90 GAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDLYLNR-------DNKFDLVLSGYFM 147
            ..:||    |...|....:.::.:.:...:..|    .:|..||:       ::|||::|:.
Human    99 YGVSK----NTFWSYFSQLQELCWEYYDYSNKL----CKDAVLNKKLMMKLQESKFDVILAD--- 152

  Fly   148 NVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPSISDSVEKGKG------------- 199
                              |..|..:||..|...|...:...|:..:.||..|
Human   153 ------------------ALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVM 199

  Fly   200 ------MSFRQRLAGYSS----SFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIF 254
                  |.|.:|:.....    .|:|.|:|.   ::..:.|.|:.|....:   .|.:....:..
Human   200 SELSDQMIFMERIKNMIHMLYFDFWFQIYDL---KKWDQFYSEVLGRPTTL---FETMGKAEMWL 258

  Fly   255 FASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHINP 318
            ..::...|.| ||.:|....:||:..|.. .|||:.|.||: .:..:|.::.||||.:  |:::.
Human   259 IRTYWDFEFP-RPFLPNVDFVGGLHCKPA-KPLPKEMEEFVQSSGENGIVVFSLGSMI--SNMSE 319

  Fly   319 DTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYS-----KWLPQDDILAHPNIKLFINHAGK 378
            ::...:.:.|:::.|:|:|:::      ||..|...|     |||||:|:|.||..|.||.|.|.
Human   320 ESANMIASALAQIPQKVLWRFD------GKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGT 378

  Fly   379 GGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKV 443
            .||.||.|||.||:.:|:|.||..|...|..:|..|:..:.::..:....|:..::::|.|.:.|
Human   379 NGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENV 443

  Fly   444 ASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYA-LIAVVLVILVL 507
            ...|.::.|:||...:..::|.|:|:||.||.||:....::::|..:::|:.| |:|.|..::.:
Human   444 MKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFI 508

  Fly   508 LLKLLLQFIYRKIFAKPKKEKK 529
            :.|..| |.:||:..|.||:|:
Human   509 ITKFCL-FCFRKLAKKGKKKKR 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	GT1_Gtf-like	24..464	CDD:340817	120/474 (25%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	138/529 (26%)