Protein Alignment Ugt37A2 and UGT2B10

DIOPT Version :10

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 135/529 - (25%)
• Similarity: 248/529 - (46%)
• Gaps: 72/529 - (13%)

  Fly    38 LIIQMST-AKVLAERGHNVTVITVLKPVVNHKNITVIMVPLTKEESQQMSDTI--GAMSKTDNSN 99
            |.:.|.| .|.|.:|||.|||:.        .:.:::..|   .:|..:...:  .:::||:..|
Human    34 LWMNMKTILKELVQRGHEVTVLA--------SSASILFDP---NDSSTLKLEVYPTSLTKTEFEN 87

  Fly   100 MILSMLRMMGQME---FMF-----DKMAGALKD---DRVRDLYLNR-------DNKFDLVLSGYF 146
            :|:.:::.:.:::   |..     .::..|:.|   :..:|:..|:       :::||:|.:..:
Human    88 IIMQLVKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMKKLQESRFDIVFADAY 152

  Fly   147 MNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGN----PLEIAYVP----SISDSVEKGKGMSFR 203
            :...:| .|:....|.:...:..|........|.    |   :|||    .:||.      |:|.
Human   153 LPCGEL-LAELFNIPFVYSHSFSPGYSFERHSGGFIFPP---SYVPVVMSKLSDQ------MTFM 207

  Fly   204 QRLAGYSSSFFFGI-FDFVTQRRSKRLYKELFGDDPNMPEYSE-----LVKNTSLIFFASHAPSE 262
            :|:.......:|.. |.....::..:.|.|:.|....:.|...     |::| |..|...|
Human   208 ERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLGRPTTLSETMRKADIWLMRN-SWNFKFPH---- 267

  Fly   263 GPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHINPDTVVKMFN 326
             |..|||..   :||:..|.. .|||:.|.||: .:..:|.::.||||.|  |::..:....:..
Human   268 -PFLPNVDF---VGGLHCKPA-KPLPKEMEEFVQSSGENGVVVFSLGSMV--SNMTEERANVIAT 325

  Fly   327 VLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPM 391
            .|:|:.|:|:|:: |..|......|....||:||:|:|.||..:.||.|.|..||.||.|||.||
Human   326 ALAKIPQKVLWRF-DGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPM 389

  Fly   392 LSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMS 456
            :.:|:|.|||.|...|..:|..:.....::.......|:..::::|.|.:.:...|.:..|:|:.
Human   390 VGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQPVK 454

  Fly   457 ARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYA-LIAVVLVILVLLLKLLLQFIYRKI 520
            ..:..::|.|:|:||.||.||:....::::...:::|:.. |:|.|..:|.::.|..| |.:.|.
Human   455 PLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLACVATVLFIITKCCL-FCFWKF 518

  Fly   521 FAKPKKEKK 529
            ..|.||.|:
Human   519 ARKGKKGKR 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	GT1_Gtf-like	24..464	CDD:340817	113/461 (25%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	132/524 (25%)