DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and UGT2B10

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001066.1	Gene:	UGT2B10 / 7365	HGNCID:	12544	Length:	528	Species:	Homo sapiens

Alignment Length:	529	Identity:	135/529 - (25%)
Similarity:	248/529 - (46%)	Gaps:	72/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LIIQMST-AKVLAERGHNVTVITVLKPVVNHKNITVIMVPLTKEESQQMSDTI--GAMSKTDNSN 99
            |.:.|.| .|.|.:|||.|||:.        .:.:::..|   .:|..:...:  .:::||:..|
Human    34 LWMNMKTILKELVQRGHEVTVLA--------SSASILFDP---NDSSTLKLEVYPTSLTKTEFEN 87

  Fly   100 MILSMLRMMGQME---FMF-----DKMAGALKD---DRVRDLYLNR-------DNKFDLVLSGYF 146
            :|:.:::.:.:::   |..     .::..|:.|   :..:|:..|:       :::||:|.:..:
Human    88 IIMQLVKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMKKLQESRFDIVFADAY 152

  Fly   147 MNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGN----PLEIAYVP----SISDSVEKGKGMSFR 203
            :...:| .|:....|.:...:..|........|.    |   :|||    .:||.      |:|.
Human   153 LPCGEL-LAELFNIPFVYSHSFSPGYSFERHSGGFIFPP---SYVPVVMSKLSDQ------MTFM 207

  Fly   204 QRLAGYSSSFFFGI-FDFVTQRRSKRLYKELFGDDPNMPEYSE-----LVKNTSLIFFASHAPSE 262
            :|:.......:|.. |.....::..:.|.|:.|....:.|...     |::| |..|...|
Human   208 ERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLGRPTTLSETMRKADIWLMRN-SWNFKFPH---- 267

  Fly   263 GPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHINPDTVVKMFN 326
             |..|||..   :||:..|.. .|||:.|.||: .:..:|.::.||||.|  |::..:....:..
Human   268 -PFLPNVDF---VGGLHCKPA-KPLPKEMEEFVQSSGENGVVVFSLGSMV--SNMTEERANVIAT 325

  Fly   327 VLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPM 391
            .|:|:.|:|:|:: |..|......|....||:||:|:|.||..:.||.|.|..||.||.|||.||
Human   326 ALAKIPQKVLWRF-DGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPM 389

  Fly   392 LSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMS 456
            :.:|:|.|||.|...|..:|..:.....::.......|:..::::|.|.:.:...|.:..|:|:.
Human   390 VGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQPVK 454

  Fly   457 ARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYA-LIAVVLVILVLLLKLLLQFIYRKI 520
            ..:..::|.|:|:||.||.||:....::::...:::|:.. |:|.|..:|.::.|..| |.:.|.
Human   455 PLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLACVATVLFIITKCCL-FCFWKF 518

  Fly   521 FAKPKKEKK 529
            ..|.||.|:
Human   519 ARKGKKGKR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	122/487 (25%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	132/524 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840