Protein Alignment Ugt37A2 and UGT2B4

DIOPT Version :9

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 142/547 - (25%)
• Similarity: 251/547 - (45%)
• Gaps: 54/547 - (9%)

  Fly     9 LLLATAICVL--GGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKN-- 69
            |||....|..  |.|  ..:|...|..  ||.:...:....|.:|||.|||:.....:....|
Human     9 LLLIQLSCYFSSGSC--GKVLVWPTEF--SHWMNIKTILDELVQRGHEVTVLASSASISFDPNSP 69

  Fly    70 ----ITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDL 130
                ..|..|.|||.|.:.:...:.........:...|....:.::.:.|:.:......|.|.:.
Human    70 STLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNK 134

  Fly   131 YLNR---DNKFDLVLSGYFMNVYQLG--FAKKVKAPVIVVATMPPNQLLNPLIGNPL-EIAYVPS 189
            .|.:   :::||:||:.   .|:..|  .|:.:|.|.:......|...:....|..| ..:|||.
Human   135 KLMKKLQESRFDVVLAD---AVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPV 196

  Fly   190 ISDSVEKGKGMSFRQRLAG----YSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSE----- 245
            :..  |....|:|.:|:..    ....|:|.|||   .::..:.|.|:.|....:.|...
Human   197 VMS--ELSDQMTFIERVKNMIYVLYFEFWFQIFD---MKKWDQFYSEVLGRPTTLSETMAKADIW 256

  Fly   246 LVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGS 309
            |::|    ::....|.  |:.|||..   :||:..|.. .|||:.|.||: .:..:|.::.||||
Human   257 LIRN----YWDFQFPH--PLLPNVEF---VGGLHCKPA-KPLPKEMEEFVQSSGENGVVVFSLGS 311

  Fly   310 NVKGSHINPDTVVKMFNVLSKLKQRVIWKWE-DLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFI 373
            .|  |:.:.:....:.:.|:|:.|:|:|::: :...|.|.:..::  ||:||:|:|.||..:.||
Human   312 MV--SNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLY--KWIPQNDLLGHPKTRAFI 372

  Fly   374 NHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQ 438
            .|.|..||.||.|||.||:.:|:|.|||.|...|..:|..::....::.......|:..::::|.
Human   373 THGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPL 437

  Fly   439 YFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYA-LIAVVL 502
            |.:.....|.::.|:|:...:..::|.|:|:||.||.||:.....:::...:::|:.. |:|.|.
Human   438 YKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVA 502

  Fly   503 VILVLLLKLLLQFIYRKIFAKPKKEKK 529
            .::.::.|.|  |...|.....||.|:
Human   503 TVIFIITKCL--FCVWKFVRTGKKGKR 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	131/505 (26%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	136/528 (26%)
		UDPGT	24..524	CDD:278624	133/525 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840