DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and UGT2A2

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001099147.2	Gene:	UGT2A2 / 574537	HGNCID:	28183	Length:	536	Species:	Homo sapiens

Alignment Length:	558	Identity:	136/558 - (24%)
Similarity:	253/558 - (45%)	Gaps:	76/558 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLG--------GCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVI----T 59
            ::.|..|.:.:.|        |.|..||          .:|::     .|.:|.|||||:    |
Human    18 VFNLTLTEVVLSGNVLIWPTDGSHWLNI----------KIILE-----ELIQRNHNVTVLASSAT 67

  Fly    60 VL------KPVVNHKNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKM 118
            :.      .||    |..||.|...|.....:.:.: .|...|:....|::.....::..:.|..
Human    68 LFINSNPDSPV----NFEVIPVSYKKSNIDSLIEHM-IMLWIDHRPTPLTIWAFYKELGKLLDTF 127

  Fly   119 --------AGALKDDRVRDLYLNRDNK--FDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQL 173
                    .|.||:.::    :.|..|  ||::::........| .|.|:..|.:......|...
Human   128 FQINIQLCDGVLKNPKL----MARLQKGGFDVLVADPVTICGDL-VALKLGIPFMYTLRFSPAST 187

  Fly   174 LNPLIGN-PLEIAYVP-SISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQR---RSKRLYKEL 233
            :....|. |..::||| ::|:..::   |:|.:|:   .::..:.:.|::.|.   .....|.::
Human   188 VERHCGKIPAPVSYVPAALSELTDQ---MTFGERI---KNTISYSLQDYIFQSYWGEWNSYYSKI 246

  Fly   234 FGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GN 297
            .|....:   .|.:....:....::...|.| ||.:|....:||:..|.. .|||:.|.||: .:
Human   247 LGRPTTL---CETMGKAEIWLIRTYWDFEFP-RPYLPNFEFVGGLHCKPA-KPLPKEMEEFIQSS 306

  Fly   298 ATDGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLE-KTPGKSDNIFYSKWLPQD 361
            ..:|.::.||||.||  ::..:....:.:.|:::.|:|:|:::..: .|.|.:..:|  .|:||:
Human   307 GKNGVVVFSLGSMVK--NLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWIPQN 367

  Fly   362 DILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPF 426
            |:|.||..|.||.|.|..||.||.|||.||:.:|:|.|||.|...|..:|..:..:|.::.....
Human   368 DLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDL 432

  Fly   427 KEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANN 491
            ..|:..:::.|.|.:.....|.::.|:|:...:..::|.|:|:||.||.||:.....:::...::
Human   433 LSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHS 497

  Fly   492 IDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            :|:...:.|.:...:.|:.....|..:| |.|..|:||
Human   498 LDVIGFLLVCVTTAIFLVIQCCLFSCQK-FGKIGKKKK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	126/516 (24%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	128/533 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840