DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt8

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	543	Identity:	140/543 - (25%)
Similarity:	248/543 - (45%)	Gaps:	80/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLLLATAICVLGG--CHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLK----PVVN 66
            :.:|||.:..|..  ...|.|:.|...:..|||.|..:.|..|...||: ||..|.:    |..|
Zfish     4 FFVLATLLWCLATSLSWAAKIVVVPPIMFESHLYIFKTLASALHAEGHD-TVFLVSEGREIPPSN 67

  Fly    67 HKNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDLY 131
            |               .::....|..:.|...:.:.|.:|.      :|.....||:...:.|.|
Zfish    68 H---------------YRLQRYPGIFNSTSADDFLQSKVRN------IFSGRLTALELFDILDHY 111

  Fly   132 ----------------LNRDNKFDLVL------SGYFMNVYQLGFAKKVKAPVIVVATMPPNQLL 174
                            |.|:: |||:|      .| |:..:.||    |:..|.......|.:
Zfish   112 SQNCDAVVGSTSVMEQLKREH-FDLLLVDPNEMCG-FVIAHILG----VQYAVFSTGLWYPAE-- 168

  Fly   175 NPLIGNPLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFF--FGIFDFVTQRRSKRLYKELFGDD 237
               :|.|..::|||..:..:.  ..||..||:|..:....  ||: .|:...:..|:.:: :...
Zfish   169 ---VGAPAPLSYVPEFNSLLT--DHMSLFQRVANTAVYLVSRFGV-QFLVLPKYDRIMRK-YNIQ 226

  Fly   238 PNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNA-TDG 301
            |::..: :||:|:.|....:....|.| ||.:|..:.:|||..| .|.||||....::.:. .||
Zfish   227 PSVSMH-DLVQNSRLWMLCTDMALEFP-RPTLPHVVYVGGILTK-PPSPLPQEFETWVKDTDEDG 288

  Fly   302 AILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAH 366
            .:::|.|:.||  :::.|...|:...||:|.|||||::..:..: ...:|.....|:||:|:|..
Zfish   289 FVVVSFGAGVK--YLSDDIAQKLAGALSRLPQRVIWRFSGVPPS-NLGNNTKLVDWMPQNDLLGQ 350

  Fly   367 PNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVK---QGFGLTQSLLSLEEQPFKE 428
            .|.:.|::|.|...|.||.|||.|::.:|:|||   :.|.|.:   :|.|:......:.|:....
Zfish   351 TNTRAFLSHGGLNSIYEAMYHGVPVVGVPLFGD---HYDTMTRVQAKGMGIMLEWKRMSEEDLYT 412

  Fly   429 AILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNID 493
            |::.::::.:|.::....|.:::|:|.......:||..|::||.||.||:|.:..:.......:|
Zfish   413 AMVNVITDKRYRERAQLLSQIHKDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLD 477

  Fly   494 IYALIAVVLVILVLLLKLLLQFI 516
            :..:|.|.|::....|..:::||
Zfish   478 VAMVIGVCLLLTGYCLYRIVKFI 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	133/515 (26%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	134/523 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585188
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840