Protein Alignment Ugt37A2 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 150/557 - (26%)
• Similarity: 257/557 - (46%)
• Gaps: 75/557 - (13%)

  Fly     5 SGIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVN--- 66
            :|:.|||:    |........:|.|  .:..||.:......:.|..|||...|:|   |.||
Human    14 TGLLLLLS----VQPWAESGKVLVV--PIDGSHWLSMREVLRELHARGHQAVVLT---PEVNMHI 69

  Fly    67 -HKN---ITVIMVPLTKEE--------SQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMA 119
             .:|   :|...:..|::|        :|...:|...:.|...|      :.|:..|..::.:..
Human    70 KEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRS------MAMLNNMSLVYHRSC 128

  Fly   120 GALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPP-------NQLLNPL 177
            ..|..:.....:||. ..||:||:.. :|:.....||.:..|.:......|       .|..||
Human   129 VELLHNEALIRHLNA-TSFDVVLTDP-VNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNP- 190

  Fly   178 IGNPLEIAYVPSI----SDSVEKGKGMSFRQRLAG--YSSSFFFGIFDFVTQRRSKRLYKELFGD 236
                  .:|:|.:    ||.      |:|.||:..  |..:..:....|.....|  |..|||..
Human   191 ------SSYIPRLLTTNSDH------MTFMQRVKNMLYPLALSYICHAFSAPYAS--LASELFQR 241

  Fly   237 DPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNAT-- 299
            :.::   .:::.:.|:..|......:.| ||.:|..:.||||...:. .||.|....:: ||:
Human   242 EVSV---VDILSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANR-KPLSQEFEAYI-NASGE 300

  Fly   300 DGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDIL 364
            .|.::.||||.|  |.|.....:.:.:.|.|:.|.|:|::.. .:....::|....|||||:|:|
Human   301 HGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG-TRPSNLANNTILVKWLPQNDLL 362

  Fly   365 AHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEA 429
            .||..:.||.|||..|:.|:..:|.||:.:|:||||..||..|..:|.|:|.::|.:..:..:.|
Human   363 GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENA 427

  Fly   430 ILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFIAANNID 493
            :..::::..|.:.:...|||::|||:...:..::|.|:|:||.||.||: |..| :::...:::|
Human   428 LKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLD 491

  Fly   494 IYA-LIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            :.. |:||||.:..:..| ...:.|||...|..:.||
Human   492 VIGFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	136/512 (27%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	143/534 (27%)
		egt	<262..508	CDD:223071	83/252 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150624
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840