Protein Alignment Ugt37A2 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 153/566 - (27%)
• Similarity: 260/566 - (45%)
• Gaps: 85/566 - (15%)

  Fly     4 KSGIYLLLATAICVLGG--CHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVN 66
            :.|..|:|...:||||.  .|...||  ...:..||.:..:...:.|.:|||.   |.||.|..:
Human     6 QGGRPLVLGLLLCVLGPVVSHAGKIL--LIPVDGSHWLSMLGAIQQLQQRGHE---IVVLAPDAS 65

  Fly    67 -------HKNITVIMVPLTKEESQQMSDTIG-----------AMSKT-----DNSNMILSMLRMM 108
                   ...:....||..:|:.::...::|           .:.||     .:|.|:||
Human    66 LYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLS----- 125

  Fly   109 GQMEFMFDK--MAGALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPN 171
            |....:.:|  ||..            .::.||::|:..|:....: .|:.:..|.:......|.
Human   126 GCSHLLHNKELMASL------------AESSFDVMLTDPFLPCSPI-VAQYLSLPTVFFLHALPC 177

  Fly   172 QLLNPLIGNPLEIAYVP----SISDSVEKGKGMSFRQR----LAGYSSSFFFG-IFDFVTQRRSK 227
            .|.......|...:|||    |.||.      |:|.||    |..:|.:|... ::.......|:
Human   178 SLEFEATQCPNPFSYVPRPLSSHSDH------MTFLQRVKNMLIAFSQNFLCDVVYSPYATLASE 236

  Fly   228 RLYKELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMA 292
            .|.:|:...|        |:.:.|:..|.|....:.| ||.:|..:.:|||.... .:||.|...
Human   237 FLQREVTVQD--------LLSSASVWLFRSDFVKDYP-RPIMPNMVFVGGINCLH-QNPLSQEFE 291

  Fly   293 EFLGNAT--DGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYS 355
            .:: ||:  .|.::.||||.|  |.|.....:.:.:.|.|:.|.|:|::.. .:....::|....
Human   292 AYI-NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG-TRPSNLANNTILV 352

  Fly   356 KWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLS 420
            |||||:|:|.||..:.||.|||..|:.|:..:|.||:.:|:||||..||..|..:|.|:|.::|.
Human   353 KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLE 417

  Fly   421 LEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-M 484
            :..:..:.|:..::::..|.:.:...|||::|||:...:..::|.|:|:||.||.||: |..| :
Human   418 MTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDL 481

  Fly   485 SFIAANNIDIYA-LIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            ::...:::|:.. |:||||.:..:..| ...:.|||...|..:.||
Human   482 TWYQYHSLDVIGFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	GT1_Gtf-like	24..464	CDD:340817	121/475 (25%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	143/540 (26%)