DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and UGT1A1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_000454.1	Gene:	UGT1A1 / 54658	HGNCID:	12530	Length:	533	Species:	Homo sapiens

Alignment Length:	566	Identity:	153/566 - (27%)
Similarity:	260/566 - (45%)	Gaps:	85/566 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KSGIYLLLATAICVLGG--CHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVN 66
            :.|..|:|...:||||.  .|...||  ...:..||.:..:...:.|.:|||.   |.||.|..:
Human     6 QGGRPLVLGLLLCVLGPVVSHAGKIL--LIPVDGSHWLSMLGAIQQLQQRGHE---IVVLAPDAS 65

  Fly    67 -------HKNITVIMVPLTKEESQQMSDTIG-----------AMSKT-----DNSNMILSMLRMM 108
                   ...:....||..:|:.::...::|           .:.||     .:|.|:||
Human    66 LYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLS----- 125

  Fly   109 GQMEFMFDK--MAGALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPN 171
            |....:.:|  ||..            .::.||::|:..|:....: .|:.:..|.:......|.
Human   126 GCSHLLHNKELMASL------------AESSFDVMLTDPFLPCSPI-VAQYLSLPTVFFLHALPC 177

  Fly   172 QLLNPLIGNPLEIAYVP----SISDSVEKGKGMSFRQR----LAGYSSSFFFG-IFDFVTQRRSK 227
            .|.......|...:|||    |.||.      |:|.||    |..:|.:|... ::.......|:
Human   178 SLEFEATQCPNPFSYVPRPLSSHSDH------MTFLQRVKNMLIAFSQNFLCDVVYSPYATLASE 236

  Fly   228 RLYKELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMA 292
            .|.:|:...|        |:.:.|:..|.|....:.| ||.:|..:.:|||.... .:||.|...
Human   237 FLQREVTVQD--------LLSSASVWLFRSDFVKDYP-RPIMPNMVFVGGINCLH-QNPLSQEFE 291

  Fly   293 EFLGNAT--DGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYS 355
            .:: ||:  .|.::.||||.|  |.|.....:.:.:.|.|:.|.|:|::.. .:....::|....
Human   292 AYI-NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG-TRPSNLANNTILV 352

  Fly   356 KWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLS 420
            |||||:|:|.||..:.||.|||..|:.|:..:|.||:.:|:||||..||..|..:|.|:|.::|.
Human   353 KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLE 417

  Fly   421 LEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-M 484
            :..:..:.|:..::::..|.:.:...|||::|||:...:..::|.|:|:||.||.||: |..| :
Human   418 MTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDL 481

  Fly   485 SFIAANNIDIYA-LIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            ::...:::|:.. |:||||.:..:..| ...:.|||...|..:.||
Human   482 TWYQYHSLDVIGFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	139/520 (27%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	143/540 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840