Protein Alignment Ugt37A2 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 150/560 - (26%)
• Similarity: 254/560 - (45%)
• Gaps: 87/560 - (15%)

  Fly    11 LATAICVL---GGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKNITV 72
            |...:|:|   |......:|.|  .:..||.....|..:.|..|||.|                |
Human    10 LPLCVCLLLTCGFAEAGKLLVV--PMDGSHWFTMRSVVEKLILRGHEV----------------V 56

  Fly    73 IMVPLTKEESQQMSDTIGAMSKTDNSNMILSML----------RMMGQMEFMFDKMAGALKDDRV 127
            :::|   |.|.|:..::....||.:::..|..|          :...|:..::..:.|:..|  :
Human    57 VVMP---EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYND--I 116

  Fly   128 RDLYLN---------------RDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPL 177
            .||:.:               :::.||.|....|.|. .|..||....|.:|.|.......|...
Human   117 FDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNC-GLIVAKYFSLPSVVFARGILCHYLEEG 180

  Fly   178 IGNPLEIAYVPSI----SDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYK---ELFG 235
            ...|..::|||.|    ||:      |:|::|:..:       |..........|.:|   |:..
Human   181 AQCPAPLSYVPRILLGFSDA------MTFKERVRNH-------IMHLEEHLLCHRFFKNALEIAS 232

  Fly   236 DDPNMP--EYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNA 298
            :....|  || :|..:||:....:....:.| :|.:|..|.||||.... ..|||.....:: ||
Human   233 EILQTPVTEY-DLYSHTSIWLLRTDFVLDYP-KPVMPNMIFIGGINCHQ-GKPLPMEFEAYI-NA 293

  Fly   299 T--DGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQD 361
            :  .|.::.||||.|  |.|.....:.:.:.|.|:.|.|:|::.. .:....::|....|||||:
Human   294 SGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG-TRPSNLANNTILVKWLPQN 355

  Fly   362 DILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPF 426
            |:|.||..:.||.|||..|:.|:..:|.||:.:|:||||..||..|..:|.|:|.::|.:..:..
Human   356 DLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL 420

  Fly   427 KEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFIAAN 490
            :.|:..::::..|.:.:...|||::|||:...:..::|.|:|:||.||.||: |..| :::...:
Human   421 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYH 484

  Fly   491 NIDIYA-LIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            ::|:.. |:||||.:..:..| ...:.|||...|..:.||
Human   485 SLDVIGFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	GT1_Gtf-like	24..464	CDD:340817	122/475 (26%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	144/540 (27%)