Protein Alignment Ugt37A2 and UGT1A6

DIOPT Version :9

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 151/563 - (26%)
• Similarity: 256/563 - (45%)
• Gaps: 88/563 - (15%)

  Fly     5 SGIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVN--- 66
            :|::.|....:.|     |..:|.|  ....||.:......:||::|||.:.|:.   |.||
Human    13 AGVFFLALWGMVV-----GDKLLVV--PQDGSHWLSMKDIVEVLSDRGHEIVVVV---PEVNLLL 67

  Fly    67 --HKNIT--VIMVPLTKEESQQMSDTIG-----------AMSKTDNSNMILSMLRMMGQMEFMFD 116
              .|..|  :..||..:||.:....:.|           |......:|||:..|..:.....:.|
Human    68 KESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQD 132

  Fly   117 KMAGALKDDRVRD-LYLNRDNKFDLVLS------GYFMNVYQLGFAKKVKAPVIVVATMPPNQLL 174
                       || |...:::|||.:.:      |..:..| ||.      |.:.:....|..|.
Human   133 -----------RDTLNFFKESKFDALFTDPALPCGVILAEY-LGL------PSVYLFRGFPCSLE 179

  Fly   175 NPLIGNPLEIAYVP----SISDSVEKGKGMSFRQRLAGY-----SSSFFFGIFDFVTQRRSKRLY 230
            :....:|..::|:|    ..||.      |:|.||:|.:     ....|:.:|....:..|..|.
Human   180 HTFSRSPDPVSYIPRCYTKFSDH------MTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLK 238

  Fly   231 KELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL 295
            :::        :...|.:..|:.........|.| ||.:|..:.||||..|...| |.|....::
Human   239 RDV--------DIITLYQKVSVWLLRYDFVLEYP-RPVMPNMVFIGGINCKKRKD-LSQEFEAYI 293

  Fly   296 GNAT--DGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWL 358
             ||:  .|.::.||||.|  |.|.....:.:.:.|.|:.|.|:|::.. .:....::|....|||
Human   294 -NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG-TRPSNLANNTILVKWL 354

  Fly   359 PQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEE 423
            ||:|:|.||..:.||.|||..|:.|:..:|.||:.:|:||||..||..|..:|.|:|.::|.:..
Human   355 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS 419

  Fly   424 QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFI 487
            :..:.|:..::::..|.:.:...|||::|||:...:..::|.|:|:||.||.||: |..| :::.
Human   420 EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWY 483

  Fly   488 AANNIDIYA-LIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            ..:::|:.. |:||||.:..:..| ...:.|||...|..:.||
Human   484 QYHSLDVIGFLLAVVLTVAFITFK-CCAYGYRKCLGKKGRVKK 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	137/518 (26%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	143/539 (27%)
		UDPGT	27..523	CDD:278624	145/540 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840