DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and UGT1A8

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_061949.3	Gene:	UGT1A8 / 54576	HGNCID:	12540	Length:	530	Species:	Homo sapiens

Alignment Length:	539	Identity:	147/539 - (27%)
Similarity:	250/539 - (46%)	Gaps:	46/539 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHK-----N 69
            |..:.:...|......:|.|  .:..||.....|..:.|..|||.|.|:   .|.|:.:     |
Human    12 LCVSLLLTCGFAEAGKLLVV--PMDGSHWFTMQSVVEKLILRGHEVVVV---MPEVSWQLGKSLN 71

  Fly    70 ITV--IMVPLTKEE-SQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDLY 131
            .||  .....|.|: .::..|...|..|....::....|........:|.....:|.:||....|
Human    72 CTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEY 136

  Fly   132 LNRDNKFDLVLSGYFMNVYQ---LGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPSI--- 190
            | :::.||.|    |::.:.   |..||....|.:|.|.......|......|..::|||.|
Human   137 L-KESSFDAV----FLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILLG 196

  Fly   191 -SDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIF 254
             ||:      |:|::|:..:.......:|.....:.:..:..|:.  ...:..| :|..:||:..
Human   197 FSDA------MTFKERVRNHIMHLEEHLFCQYFSKNALEIASEIL--QTPVTAY-DLYSHTSIWL 252

  Fly   255 FASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNAT--DGAILLSLGSNVKGSHIN 317
            ..:....:.| :|.:|..|.||||.... ..|||.....:: ||:  .|.::.||||.|  |.|.
Human   253 LRTDFVLDYP-KPVMPNMIFIGGINCHQ-GKPLPMEFEAYI-NASGEHGIVVFSLGSMV--SEIP 312

  Fly   318 PDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGIT 382
            ....:.:.:.|.|:.|.|:|::.. .:....::|....|||||:|:|.||..:.||.|||..|:.
Human   313 EKKAMAIADALGKIPQTVLWRYTG-TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVY 376

  Fly   383 EAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFS 447
            |:..:|.||:.:|:||||..||..|..:|.|:|.::|.:..:..:.|:..::::..|.:.:...|
Human   377 ESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLS 441

  Fly   448 SLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIYA-LIAVVLVILVLLLK 510
            ||::|||:...:..::|.|:|:||.||.||: |..| :::...:::|:.. |:||||.:..:..|
Human   442 SLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK 505

  Fly   511 LLLQFIYRKIFAKPKKEKK 529
             ...:.|||...|..:.||
Human   506 -CCAYGYRKCLGKKGRVKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	134/497 (27%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	143/521 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840