Protein Alignment Ugt37A2 and UGT2B28

DIOPT Version :10

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 131/538 - (24%)
• Similarity: 233/538 - (43%)
• Gaps: 87/538 - (16%)

  Fly    36 SHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKNITVIMVPLTKEESQQMSDTIGAMSKTDNSNM 100
            ||.:...:..|.|.:|||.|||:.....::...|....:    |.|....|     ::||:..|:
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTL----KLEVYPTS-----LTKTEFENI 89

  Fly   101 ILSMLRMMGQMEFMFDKMAGALKDD-------------RVRDLYLN---------------RDNK 137
            |:..::....::          ||.             ...|::.|               ::::
Human    90 IMQQVKRWSDIQ----------KDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESR 144

  Fly   138 FDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLL----NPLIGNPLEIAYVP----SISDSV 194
            ||::.:..|....:| .|..:..|.:......|...:    ..||..|   :|:|    .:||.
Human   145 FDIIFADAFFPCGEL-LAALLNIPFVYSLCFTPGYTIERHSGGLIFPP---SYIPVVMSKLSDQ- 204

  Fly   195 EKGKGMSFRQRLAGYSSSFFFGI-FDFVTQRRSKRLYKELFGDDPNMPEYSE-----LVKNTSLI 253
                 |:|.:|:.......:|.. |.....::..:.|.|:.|....:.|...     |::| |..
Human   205 -----MTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRN-SWS 263

  Fly   254 FFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHIN 317
            |...|     |..||:..   :||:..|.. .|||:.|.||: .:..:|.::.||||.:  |::.
Human   264 FQFPH-----PFLPNIDF---VGGLHCKPA-KPLPKEMEEFVQSSGENGVVVFSLGSVI--SNMT 317

  Fly   318 PDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGIT 382
            .:....:...|:|:.|:|:|:: |..|......|....||:||:|:|..|..:.||.|.|..||.
Human   318 AERANVIATALAKIPQKVLWRF-DGNKPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIY 381

  Fly   383 EAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFS 447
            ||.|||.||:.:|:|.|||.|...|..:|..:.....::.......|:..::::|.|.:.|...|
Human   382 EAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLS 446

  Fly   448 SLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYA-LIAVVLVILVLLLKL 511
            .:..|:|:......::|.|:|:.|.||.||:.....:::...:::|:.. |:|.|..::.::.|.
Human   447 IIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLDVIGFLLACVATVIFVVTKF 511

  Fly   512 LLQFIYRKIFAKPKKEKK 529
            .| |.:.|...|.||.|:
Human   512 CL-FCFWKFARKGKKGKR 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	GT1_Gtf-like	24..464	CDD:340817	111/470 (24%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	128/533 (24%)