DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt302C1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	176/542 - (32%)
Similarity:	278/542 - (51%)	Gaps:	38/542 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KSGIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVIT---VLKPVV 65
            ::|...||  ..|:|......|.|.|..:.:.||..:..:.||.||..||.||:|:   :.||:.
  Fly     7 QTGFLALL--LFCLLSCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIK 69

  Fly    66 NHKNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDL 130
            |.|::.      .|.....|...|..:.::....:|..::. ..:|.....::  .||:..|.:|
  Fly    70 NIKDVP------AKSILTSMQGRIANLLQSSKEPIIKQIIN-FHEMGIEITEL--LLKEPSVIEL 125

  Fly   131 YLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPS----IS 191
             :..:..||.|:|..|:|....|||:..|||:|.:.|.........|:|:|...:||||    .|
  Fly   126 -MKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPSPPSYVPSALLKFS 189

  Fly   192 DSVEKGKGMSFRQRLAGYSSSFFFGIF-DFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFF 255
            |.      ||..:|:...:...:..|| ::....|.:.||::.|.:  |..::.::.|||:|:..
  Fly   190 DR------MSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPN--NKQDFYDMRKNTALVLL 246

  Fly   256 ASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGSHINPDT 320
            ..|.....| ||..|..||:||:.:.....|||:::.||:..|..|.|..|:|||:|...:..:.
  Fly   247 NQHVSLSFP-RPYSPNMIEVGGMHINRKRQPLPKDILEFIEGAEHGVIYFSMGSNLKSKTLPLEK 310

  Fly   321 VVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQ 385
            ...:.:..::|||||:||:||.: .|||..|:|.|.|.||||||||.|:..||.|.|....||:.
  Fly   311 RQALIDTFAQLKQRVLWKFEDTD-LPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESI 374

  Fly   386 YHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLY 450
            ||.||.:.:|:||||..|.....:.|:|:|.....|.......||.:|::||:...:|...|..|
  Fly   375 YHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRY 439

  Fly   451 RDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNID----IYALIAVVLVILVLLLKL 511
            ||:..:..|..:||.|:|.||.||.:|:|....::||..:|:|    :|..|..||..:.||::|
  Fly   440 RDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRL 504

  Fly   512 ---LLQFIY-RKIFAKPKKEKK 529
               |||.:: :|..:|||::.|
  Fly   505 VWRLLQELFIKKDTSKPKQKAK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	158/489 (32%)
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	127/359 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445717
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950