DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt302E1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	174/535 - (32%)
Similarity:	270/535 - (50%)	Gaps:	36/535 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVL---KPVVNHKN 69
            :|||..|:  .|...|.:.|.:..:.|.||..:..:.||.||..||.||:::..   ||:   ||
  Fly     8 WLLLILAL--FGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPI---KN 67

  Fly    70 ITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFM-FDKMAGALKDDRVRDLYLN 133
            |..:       |:..:...:|........|....:|....::..| .|.....||:.:|::| |.
  Fly    68 IIDV-------ETPNIITVMGVYKARILENAKKPVLLRYPRISLMGLDITESLLKEPKVQEL-LK 124

  Fly   134 RDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPSISDSVEKGK 198
            ::..||.|:...|||....|||:...||:|.::::......:.|:|.|...:|||  ...:..|.
  Fly   125 QNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVP--HSLLRFGD 187

  Fly   199 GMSFRQRLAGYSSSFFFGIFDFVTQR-----RSKRLYKELFGDDPNMPEYSELVKNTSLIFFASH 258
            .|:|.:|    :.:..|.|::|..:.     |.:.||::.|.:  |..::..:.|:|||:...:|
  Fly   188 RMNFWER----AQNLGFQIYEFAYENLINLPRHEALYRKYFPN--NKQDFYRMRKDTSLVLLNNH 246

  Fly   259 APSEGPIRPNVPAAIEIGGIQV-KDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGSHINPDTVV 322
            .....| ||..|..||:||:.| :..|.|||||:.:|:..|..|.|..|||||:....:..:...
  Fly   247 VSISNP-RPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFSLGSNLNSKDLPENKRK 310

  Fly   323 KMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYH 387
            .:...|..||.|||||:|: |....|.||:..|.||||||||||..:..||.|.|.....|:.||
  Fly   311 AIVETLRGLKYRVIWKYEE-ETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYH 374

  Fly   388 GKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRD 452
            |||::.:|.||||..|.....:.|:|:|.....|....|:.||..|.|:|.:.::|...||.|||
  Fly   375 GKPVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRD 439

  Fly   453 RPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQF-- 515
            :..:..|..:||.|:|.||.||.:|:|....::||..:|:|:.|....|:.:.|:.:.||::|
  Fly   440 QKETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLLVRFLV 504

  Fly   516 -IYRKIFAKPKKEKK 529
             |......||..:.|
  Fly   505 TIVNGFLYKPSSKLK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	162/491 (33%)
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	129/360 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445718
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950