DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt302K1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	170/530 - (32%)
Similarity:	271/530 - (51%)	Gaps:	34/530 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVL---KPVVNHKN 69
            :.|:...:|.||...|.|.|.|..|...||..:..:.||.|.:.||.:||::|.   ||:..:.:
  Fly     4 FTLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTD 68

  Fly    70 ITVIMVPLTKEESQQMSDTIGAM----SKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDL 130
            ::|..|      .:.|...|||:    .||...|:|...     ||.|...:  |..:|...:|
  Fly    69 VSVPNV------IEVMGGDIGALWASIQKTYTQNLIDHY-----QMGFRITR--GLFEDSNFQD- 119

  Fly   131 YLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPSISDSVE 195
            :|..:..||.::...|.|....|.|:...||:|.:||......:..::|:|...::||.|  .:.
  Fly   120 FLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVPHI--MLP 182

  Fly   196 KGKGMSFRQRLAGYSSSFFFG----IFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFFA 256
            ....||..:||...:   |.|    :.|:......::||||.|  ..|...:.::.:|.||:...
  Fly   183 FNDHMSLYERLLNVA---FLGYERVLLDYYFLPTQEKLYKEFF--PGNKRCFYKMRRNASLVLIN 242

  Fly   257 SHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGSHINPDTV 321
            .|.....| ||:.|..||:||:.:....:|||:.:..|:..:..|||..|:|||:|...:.|..|
  Fly   243 QHVSLSFP-RPHSPNMIEVGGMHIDGKWNPLPEKIERFINESEHGAIYFSMGSNLKTKDLPPSKV 306

  Fly   322 VKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQY 386
            .::...|..|||||:||:| |:..|.|.:|::.|.|.||.||||||.|..|:.|.|....||:.|
  Fly   307 QEILKALGGLKQRVLWKFE-LDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIY 370

  Fly   387 HGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYR 451
            |.||::.||:|.||..|.....:.|:|:.....:|....|::||..|.|.|.|...|...|..||
  Fly   371 HAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYR 435

  Fly   452 DRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFI 516
            |:..:..|:.|||.|:|.||.|||:|:|....:::...:|:|:..:|.||:|:|:::|.:.:..:
  Fly   436 DQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPITIYKL 500

  Fly   517 YRKIFAKPKK 526
            .:|:..|.::
  Fly   501 LKKLLLKGER 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	160/492 (33%)
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	162/498 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445715
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950