DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt49B2

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	176/548 - (32%)
Similarity:	269/548 - (49%)	Gaps:	67/548 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNH--KNITVIMVPL 77
            :|:||...||.||..|.....||.::..:..:.|.:|||.||.||.|.....:  .|...|::|
  Fly    10 VCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYREILLP- 73

  Fly    78 TKEESQQMSDT---IGAMSKTDNSNMILSMLRMMGQMEFMFDKMAG------ALKDDRVRDLYLN 133
                   ..||   |.||.||.::   |.|:.|.........:..|      ||....|::|...
  Fly    74 -------KYDTWADISAMMKTKSA---LDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYA 128

  Fly   134 RD--NKFDLVLSGYFMN--VYQLGFAKKVKAPVIVVATMPPNQLLNPLIG--NPLEIAYVPSISD 192
            :|  .||||:|...|.|  ...||:..::  |.|.:||.......:.:.|  |||  :|||::..
  Fly   129 KDKKGKFDLLLVEQFHNEGALMLGYIYEI--PAITIATFAYANYFSQVFGFVNPL--SYVPNVFL 189

  Fly   193 SVEKGKGMSFRQRLAGYSSS---------FFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVK 248
            |..  ..||..:||.....|         .::...|.|.::....|.       |.:|...:|.:
  Fly   190 SCT--DRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLL-------PRVPTVKQLEQ 245

  Fly   249 NTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKG 313
            |.|:|...|:.|...| ||.....|.:||:.:. .|.|||:::..:|.||..|||..||||.|:.
  Fly   246 NISVILLNSYMPLTSP-RPMSQNMISVGGLHIL-PPKPLPEHIKNYLDNAEHGAIYFSLGSQVRS 308

  Fly   314 SHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGK 378
            :.:..:.:....:|.:.|||||:||:|| ::.|...||:...|||||.|||||||:|:||.|.|.
  Fly   309 ADMPAEKLQIFLDVFASLKQRVLWKFED-DQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGL 372

  Fly   379 GGITEAQYHGKPMLSLPVFGDQPGNADVMVKQG------FGLTQSLLSLEEQPFKEAILEILSNP 437
            .|:.||.||..|:|.:|.:.||    |:.:|.|      .||....:|.::  .|.|:..:|.:|
  Fly   373 FGMQEAVYHAVPVLGMPFYFDQ----DINIKAGQAAGYAIGLDYRTISKDQ--LKSALHALLKDP 431

  Fly   438 QYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALI-AVV 501
            :|...:...|.::||||:.|.::.:||..||:.|.||.||.:..||:.:.....:|:.|:| |:.
  Fly   432 KYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAIT 496

  Fly   502 LVILVLLLKLLLQF-IYRKIFAKPKKEK 528
            |:.|:.|..:...: .:|.|.|:.|:.|
  Fly   497 LLPLLTLYAVSRNYKSFRGIRAQKKEAK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	164/506 (32%)
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	170/524 (32%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	160/498 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454749
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940