DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	171/537 - (31%)
Similarity:	268/537 - (49%)	Gaps:	42/537 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVL---KPVVNH 67
            |..||...|     ....|.||.:|....||..|..:...|.||.|||.||.:...   |||||.
  Fly     7 GFLLLTLPA-----SMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNF 66

  Fly    68 KNITVIMVP-LTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDLY 131
            ::   :.:| :.....:.:::..|.|:....:|.|         .:|........|.:..|.:..
  Fly    67 RD---VFIPDVFNNYKELINELSGPMNLWQENNFI---------NKFFVSVTRCVLTNKEVTETL 119

  Fly   132 L--NRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVP----SI 190
            |  .:|: |||::.....:....|||....||:|.::|...:..::.|:||...::|.|    .:
  Fly   120 LPPGKDH-FDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGL 183

  Fly   191 SDSVEKGKGMSFRQRLAGYSSSFFFGI-FDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIF 254
            :|.      |:|.:||:.:..:....: :.||.....:::|.:.|.:.....:.::|.:|.||:.
  Fly   184 TDR------MTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVL 242

  Fly   255 FASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHINP 318
            ...|.....| ||.||..||:||:.:...|.|||:::.||: |:...|.|..||||||....:..
  Fly   243 LNQHFSLSFP-RPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPA 306

  Fly   319 DTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITE 383
            |....:....:.|.|||:||:|| :|.|||..|:|.|||.||.||||||.:||||.|.|.....|
  Fly   307 DRKDLILKTFASLPQRVLWKFED-DKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIE 370

  Fly   384 AQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSS 448
            :.:||||:|.||.|.||..|.....:.||||.....::.:|..||.|..:|..|::.......|.
  Fly   371 SIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSE 435

  Fly   449 LYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLL 513
            .|||:|||..::.|:|||||:||.||.|::.....:.|.|.:::|:   |.|:|...:||:.:::
  Fly   436 RYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDV---IGVLLGGALLLVAIIV 497

  Fly   514 QFIYRKI-FAKPKKEKK 529
            ..:.:.. |...||:.|
  Fly   498 GVLGKLTDFGNAKKKLK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	160/493 (32%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	158/483 (33%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	135/432 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445711
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940