DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	142/553 - (25%)
Similarity:	240/553 - (43%)	Gaps:	74/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKNIT 71
            :.:.|.|.:|  |...|||:|.||.|:..||.:......:.|.|...|.:| |::.|....:.:.
  Fly     4 LQVFLGTLLC--GIVLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSV-TLISPHAAQEGVD 65

  Fly    72 VIMVPLTKE-----------------ESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKM- 118
            . .:|..:|                 |:::|                    |....|| .|.::
  Fly    66 A-EIPKIRELRIEGLRENWLDMGMSFEAEEM--------------------RAQSVME-RFTRLI 108

  Fly   119 -AGA------LKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNP 176
             ||.      |.|.:||.| |....||||::...|::...||.|.....|.:.|:....|..||.
  Fly   109 YAGTTNVDILLSDPQVRKL-LTSGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNN 172

  Fly   177 LIGNPLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFF----FGIFDFVTQR-----RSKRLYKE 232
            :.|||...:..|  |:.:...:.|:.|||:.....|.|    :..|..::|:     ..:.|.||
  Fly   173 MFGNPQSSSLDP--SNFLPFTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKE 235

  Fly   233 LFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKD-TPDPLPQNMAEFLG 296
            |       |.|.:|.||.||....||.....| |..:|..:|:||:.:.. ..|.||:::..|:.
  Fly   236 L-------PLYRDLTKNLSLALINSHPGLHYP-RAYLPNMVEVGGLHLSHLNDDNLPKHLLSFME 292

  Fly   297 NATDGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQ-RVIWKWEDLEKTPGK--SDNIFYSKWL 358
            :|..|.|..|||::|:.:.:..:.:..:.:|...||: ..:.|||..|.|..:  .:|:..:.|.
  Fly   293 SAPSGVIYFSLGADVETAQLPQEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWW 357

  Fly   359 PQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEE 423
            ||..||.||.:|:||:..|:..:.|:....||:|::|:..:|...|..:.:.|..:|....||..
  Fly   358 PQQAILHHPQVKMFISSCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAY 422

  Fly   424 QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIA 488
            ......|.::..|..|.:|:.........|..:.....:...:.::...||..|:|....::|..
  Fly   423 DSLLHGIRQLTLNTSYVEKLGQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWR 487

  Fly   489 ANNIDIYALIAVVLVILVLLLKLLLQFIYRKIF 521
            |..:|:..:|||....::.:..|.:.||.||.:
  Fly   488 AEGVDVLLIIAVGFFGILTIPFLAICFILRKSY 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	132/519 (25%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	131/511 (26%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	113/442 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445723
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.950