DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	149/554 - (26%)
Similarity:	254/554 - (45%)	Gaps:	61/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTV----ITVLKPVV 65
            ||:.|||    |.|....|..:| || .:..||.:......:.|..|||...|    :||.....
  Rat    11 SGLLLLL----CALPWAEGGKVL-VF-PMEGSHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEE 69

  Fly    66 NHKNITVIMVPLTKEESQQMSDTIGAMS---KTDNS-NMILSMLRMMGQMEFMFDKMAGALKDDR 126
            :...:....||.||||.:.  ..:|.:.   :|:.| .::|..:..:..:...:.:....|..:.
  Rat    70 DFFTLQTYPVPYTKEEYRH--HLLGHLQNFFETEFSLKLVLQRMAAVNNVSTFYVRSCRGLLHNT 132

  Fly   127 VRDLYLNRDNKFDLVLSGYFMNVYQLG--FAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPS 189
            .....|| .:.||:||:..|   :..|  .|..::.|.:........:|......:|...:|:|.
  Rat   133 ALIQSLN-SSSFDVVLTDPF---FPCGAVLAMYLRVPAVFFLQSMLCELEFEATNSPNPSSYIPR 193

  Fly   190 I----SDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNT 250
            :    ||.      |||..|:........:.....|......||..:|...:.::   .|::::.
  Rat   194 LLTLNSDH------MSFLDRVKNMLYPVPWMYLCHVNYGSLARLASDLLQREVSV---VEILRHA 249

  Fly   251 SLIF----FASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNAT--DGAILLSLGS 309
            |:..    |..:.|     ||.:|..:.||||...:. .||.|....:: ||:  .|.::.||||
  Rat   250 SVWLLRKDFVFYYP-----RPFMPNMVFIGGINCANR-KPLSQEFEAYV-NASGEHGIVVFSLGS 307

  Fly   310 NVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFIN 374
            .|  |.|.....:::...|.::.|.|:|::.. .:....:.|....|||||:|:|.||..:.||.
  Rat   308 MV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLLGHPKARAFIT 369

  Fly   375 HAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQY 439
            |:|..||.|...:|.||:.:|:||||..||..|..:|.|:|.::|.:.....:.|:..:::|..|
  Rat   370 HSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSY 434

  Fly   440 FDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIYA-LIAVVL 502
            .:.:...|||::|||:...:..::|.|||:||.||.||: |..| :::...:::|:.. |:|:||
  Rat   435 KENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVL 498

  Fly   503 VILVLLLKLLLQFIYRKIFA------KPKKEKKH 530
            .::.::.| ...:..||.|.      |..|.|.|
  Rat   499 TVVFIVYK-SCAYGCRKCFGGKGRVKKSHKSKTH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	134/502 (27%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	137/524 (26%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	89/290 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910