Protein Alignment Ugt37A2 and Ugt1a1

DIOPT Version :10

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_964007.2
• Gene: Ugt1a1 / 394436
• MGIID: 98898
• Length: 535
• Species: Mus musculus
• Alignment Length: 565
• Identity: 158/565 - (27%)
• Similarity: 264/565 - (46%)
• Gaps: 87/565 - (15%)

  Fly     8 YLLLATAICVLG--GCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVI------------ 58
            ||||    ||.|  ..|...:| || .:..||.:..:...:.|.::||.|.||
Mouse    16 YLLL----CVFGPSASHAGRLL-VF-PMDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGS 74

  Fly    59 --TVLK-PVVNHK-NITVIMVPLTKEESQQMSDTIGAMS-----KTDNSNMILSMLRMMGQMEFM 114
              |:.| ||...| |:|..:|.|.:....|.|..:..:.     |.|:|.::.....::...|||
Mouse    75 FYTLRKFPVPFQKENVTATLVELGRTAFNQDSFLLRVVKIYMKVKRDSSMLLAGCSHLLHNAEFM 139

  Fly   115 FDKMAGALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIG 179
                 .:|:           ::.||.:|:..|:....: .|:.:..|.:......|..|.:....
Mouse   140 -----ASLE-----------ESHFDALLTDPFLPCGSI-VAQYLTVPTVYFLNKLPCSLDSEATQ 187

  Fly   180 NPLEIAYVP-SISDSVEKGKGMSFRQR----LAGYSSSFFFG-IFDFVTQRRSKRLYKELFGDDP 238
            .|:.::||| |:|.:.::   |:|.||    |...|.:|... ::.......::.|.||:...|
Mouse   188 CPVPLSYVPKSLSFNSDR---MNFLQRVKNVLLAVSENFMCRVVYSPYGSLATEILQKEVTVQD- 248

  Fly   239 NMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGI---QVKDTPDPLPQNMAEFLGNAT- 299
                   |:...|:....|....:.| ||.:|..:.||||   |.|    ||.|....:: ||:
Mouse   249 -------LLSPASIWLMRSDFVKDYP-RPIMPNMVFIGGINCLQKK----PLSQEFEAYV-NASG 300

  Fly   300 -DGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDI 363
             .|.::.||||.|  |.|.....:::...|.::.|.|:|::.. .:....:.|....|||||:|:
Mouse   301 EHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDL 362

  Fly   364 LAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKE 428
            |.||..:.||.|:|..||.|...:|.||:.:|:||||..||..|..:|.|:|.::|.:.....:.
Mouse   363 LGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLEN 427

  Fly   429 AILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFIAANNI 492
            |:..:::|..|.:.:...|||::|||:...:..::|.|||:||.||.||: |..| :::...:::
Mouse   428 ALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSL 491

  Fly   493 DIYA-LIAVVLVILVLLLKLLLQFIYRKIFA------KPKKEKKH 530
            |:.. |:|:||.::.::.| ...:..||.|.      |..|.|.|
Mouse   492 DVIGFLLAIVLTVVFIVFK-CCAYGCRKCFGGKGRVKKSHKSKTH 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	GT1_Gtf-like	24..464	CDD:340817	125/471 (27%)
Ugt1a1	NP_964007.2	UDPGT	30..526	CDD:278624	146/536 (27%)