DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	554	Identity:	152/554 - (27%)
Similarity:	251/554 - (45%)	Gaps:	66/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVIT------VLKPVV 65
            :.||||:.:...|     .:|.|  .:..||.....:..:.|..:||.|.|:.      :.||:
Mouse    14 VCLLLASGLAQAG-----RLLVV--PMDGSHWFTMQTVVEKLLHKGHEVVVVVPEVSWQLTKPL- 70

  Fly    66 NHKNITV--IMVPLTKEE-SQQMSDTIGAMSKTDNSNMILSML--RMMGQMEFMFDKMAGALKDD 125
               |..|  ..|..|:|: :::....|.|..|:.....||.:|  ...|..|.:|........|.
Mouse    71 ---NFVVKTYAVSHTQEDLNREFKIFIDAQWKSQQEGGILPLLDSPAKGFFELLFSHCRSLFNDK 132

  Fly   126 RVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVP-- 188
            ::.: || :...||.|....| :|..|..||....|.:|.:.......|......|...:|:|
Mouse   133 KLVE-YL-KQTSFDAVFLDPF-DVCGLTVAKYFSLPSVVFSRGIFCHYLEDAAQCPSPPSYIPRM 194

  Fly   189 --SISDSVEKGKGMSFRQR---LAGY--SSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSEL 246
              ..:|:      |:|::|   |..|  ..:|....|.......|:.|...:...|...|....|
Mouse   195 LLKFTDT------MTFKERTRNLLAYMGERAFCHKFFKSAADIASEVLQTPVTMTDLFSPVSIWL 253

  Fly   247 VKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNAT--DGAILLSLGS 309
            ::...::.|..      |:.|||   |.||||.... ..||.:....:: ||:  .|.::.||||
Mouse   254 LRTDFVLEFPR------PVMPNV---IYIGGINCHQ-GKPLSKEFEAYV-NASGEHGIVVFSLGS 307

  Fly   310 NVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFIN 374
            .|  |.|.....:::...|.::.|.|:|::.. .:....:.|....|||||:|:|.||..:.||.
Mouse   308 MV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLLGHPKTRAFIT 369

  Fly   375 HAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQY 439
            |:|..||.|...:|.||:.:|:||||..||..|..:|.|:|.::|.:.....:.|:..:::|..|
Mouse   370 HSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSY 434

  Fly   440 FDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIYA-LIAVVL 502
            .:.:...|||::|||:...:..::|.|||:||.||.||: |..| :::...:::|:.. |:|:||
Mouse   435 KENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVL 498

  Fly   503 VILVLLLKLLLQFIYRKIFA------KPKKEKKH 530
            .::.::.| ...:..||.|.      |..|.|.|
Mouse   499 TVVFIVFK-CCAYGCRKCFGGKGRVKKSHKSKTH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	139/504 (28%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	144/531 (27%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	90/292 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840