DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt37A1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	356/530 - (67%)
Similarity:	430/530 - (81%)	Gaps:	10/530 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVHKSGIYLLLATAICVL-GGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPV 64
            ||.::..|.::..|:.:| .|..||||||:|.|||||||||.||.||:|||:||||||:|||:|.
  Fly     1 MVGRTKSYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPT 65

  Fly    65 VNHKNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRD 129
            :.||||.::.||:||||.:|.|:||||..|..:||..:|:|.|.|||:.|..|||..|||.||::
  Fly    66 ITHKNINLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVKE 130

  Fly   130 LYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPSISDSV 194
            ||||:||.||||:||||||.||||||:||.|||:|:|..||:|:||.|||||         .|.|
  Fly   131 LYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNP---------HDKV 186

  Fly   195 EKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFFASHA 259
            ||.|||:|.|||..|.||..:|||.....:|:::.|.|:|||||.||||:::::||||:||.|||
  Fly   187 EKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHA 251

  Fly   260 PSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGSHINPDTVVKM 324
            .|||||||:|||||||||||:||.|||||:|:.:||||||.|||||||||||:||||..|||.|:
  Fly   252 ASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNATHGAILLSLGSNVQGSHIKADTVKKI 316

  Fly   325 FNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGK 389
            |:|||.|||||||||:||:|||||||||.||:|||||||||||::||||||||||||:|||||||
  Fly   317 FSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGK 381

  Fly   390 PMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRP 454
            |||||||||||||||..|||.|||||.|||:|||:||:.|:|||||||:|..:|..|||||||||
  Fly   382 PMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRP 446

  Fly   455 MSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFIYRK 519
            .|||||:|:|||||||||||||||||||||.||||||:||||||..:.:.|:|:||.::|...|:
  Fly   447 ASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRR 511

  Fly   520 IFAKPKKEKK 529
            :..|..|.||
  Fly   512 LRTKLNKVKK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	335/482 (70%)
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	306/439 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445650
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H86211
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2282
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51205at7147
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm50532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	10.000