DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt36E1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	162/543 - (29%)
Similarity:	267/543 - (49%)	Gaps:	56/543 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLK---PVVNHK 68
            ::.||| .:.::.......|||:|...:.||........:.|||.||:|.||:..:   |...:|
  Fly     7 VFCLLA-LLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYK 70

  Fly    69 NITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMA-----GALKDDRVR 128
            :  .::.|.|      ::|||.........:.:...:..     |:..||.     ..|....:.
  Fly    71 D--HLLPPST------LTDTISLEDFERPYSFLFHYVEF-----FILHKMGREDCNTTLHSRALT 122

  Fly   129 DLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVV---ATMPPNQLLNPLIGNPLEIAYVPSI 190
            ::..|....:|::|...|.....:..|...:||||.:   |.||.:.   ...|.||    :||.
  Fly   123 EILKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHY---ERFGAPL----IPSY 180

  Fly   191 SDSVEKGKG--MSFRQRLAG----YSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKN 249
            ..::.:|:.  |||..||..    :|.:..:.:|   |......|.::.||  |.:|...:||:|
  Fly   181 ISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMF---TVPAGNALIRQRFG--PGLPSTEDLVRN 240

  Fly   250 TSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGS 314
            |||:....|....|| :|..|..||:||:.: ..|.|||.::.:.|.||..|.||:|.||.:|..
  Fly   241 TSLMLVNQHFSLSGP-KPLPPNVIEVGGVHI-SPPKPLPSDLQKILDNAPKGVILISWGSQLKAC 303

  Fly   315 HINP---DTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHA 376
            .::.   |.:||   .:.:|:|.||||:|: :..|.|..|:...|||||.|||||||:|:|::|.
  Fly   304 SLSAARRDGIVK---AIGRLEQEVIWKYEN-DTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHG 364

  Fly   377 GKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFD 441
            |..|.|||.....|::.:|::|||..|...:|::|..|...|..|:|....||:.:.| :|.:..
  Fly   365 GLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKA 428

  Fly   442 KVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILV 506
            :....:|.|.:|.....|:.|:|.|:|....||...|...||:|.....::|:|:::|:.|::.|
  Fly   429 RAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPV 493

  Fly   507 LLLKLLLQFIYRKIFAKPKKEKK 529
            :.|..|::...|:   :||.::|
  Fly   494 ITLLGLIRMFKRR---EPKGDRK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	151/501 (30%)
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	145/485 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454631
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940