DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt301D1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	150/511 - (29%)
Similarity:	247/511 - (48%)	Gaps:	67/511 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKNITVIMVP--------LTK 79
            |:.||.:....:|||.:........|..:||:||.:........|:|:|.|::.        ..|
  Fly    24 GSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISPSFDIPKHFPK 88

  Fly    80 E---ESQQMSD--------TIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDLYLN 133
            |   ..|.:||        |||.|: |::                       |.||.:|:.|..:
  Fly    89 ENIFSMQFVSDFNNLELWWTIGLMT-TEH-----------------------AFKDPKVKKLIES 129

  Fly   134 RDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPSISDSVEKGK 198
            :|:.:|||:...|.:...|.|.|:...||:.:.||.....::..:|.....:.:|.:  .:....
  Fly   130 KDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIPHL--LLSHTD 192

  Fly   199 GMSFRQRLAGYSSSFFFGIFDFVTQR-----RSKRLYKELFG---DDPNMPEYSELVKNTSLIFF 255
            .|:|.||  .|::  :..::|.|.:|     :.::|.::.|.   :.| :|...:|.:|.||:..
  Fly   193 RMTFGQR--AYNA--YLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGP-LPNVLDLERNISLVLI 252

  Fly   256 ASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGSHINPDT 320
            .:|...:.| ||::|..|::||..:: .|..||.::..||.|||.|.|..|:||.||.:.:..:.
  Fly   253 NAHRSIDLP-RPSMPGLIDVGGAHIQ-KPKQLPTDLQNFLDNATYGVIYFSMGSYVKSTDLPQEK 315

  Fly   321 VVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQ 385
            ...:.....:|||:||||:|: :.......|:...||:||:|||||||:||||.|.|..|..|..
  Fly   316 TALILKAFGQLKQQVIWKFEN-DSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGI 379

  Fly   386 YHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLY 450
            |.|.|||.:|::|||..|....|::|:..:.....|........|..::::|||.......|..:
  Fly   380 YWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRF 444

  Fly   451 RDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILV 506
            ||.|:...:...:|.||:|||.||.||:|   |.:||..:.   |.|:.|:..:|:
  Fly   445 RDNPIHPLDEATFWIEYIIRHRGARHLKS---HGAFIPLHQ---YLLLDVLGCLLL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	146/493 (30%)
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	146/498 (29%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	142/485 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	6.010