DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	151/553 - (27%)
Similarity:	259/553 - (46%)	Gaps:	64/553 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKP----VVNHK- 68
            |||..:.|:.....|..::   ..:..||.:...:....|.:|||.|   |||||    |::.|
  Rat    10 LLLQISFCLRSAKCGKVLV---WPMEFSHWMNIKTILDELVQRGHEV---TVLKPSAYYVLDPKK 68

  Fly    69 ----NITVIMVPLTKEESQQ-MSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVR 128
                ........::|:|.:: ....:.|.:.....:..||...::..|.            |...
  Rat    69 SPDLKFETFPTSVSKDELEKYFIKLVDAWTYELQRDTCLSFSPLLQNMM------------DEFS 121

  Fly   129 DLYLN---------------RDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLI 178
            |.||:               :::|||::||.......:| .|:.:..|.:......|...:....
  Rat   122 DYYLSVCKDAVSNKQLMAKLQESKFDVLLSDPVAACGEL-IAEVLHIPFLYSLRASPGHKIEKSS 185

  Fly   179 GN-PLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGI-FDFVTQRRSKRLYKELFGDDPNMP 241
            |. .|..:|||.|...:  |..|:|..|:.......:|.. |.....:.....|.|:.|....:
  Rat   186 GRFILPPSYVPVILSGL--GGQMTFIDRVKNMICMLYFDFWFHMFNAKNWDPFYTEILGRPTTL- 247

  Fly   242 EYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATD-GAILL 305
              :|.:....:....|:...|.| .|.:|....|||:|.|.. .|||:::.:|:.::.: |.::.
  Rat   248 --AETMGKAEMWLIRSYWDLEFP-HPTLPNVDYIGGLQCKPA-KPLPKDIEDFVQSSGEHGVVVF 308

  Fly   306 SLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWE-DLEKTPGKSDNIFYSKWLPQDDILAHPNI 369
            ||||.|  |.:..:....:...|:::.|:|:||:: .:..|.|.:..::  |||||:|:|.||..
  Rat   309 SLGSMV--SSMTEEKANAVAWALAQIPQKVLWKFDGKIPATLGPNTRVY--KWLPQNDLLGHPKT 369

  Fly   370 KLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEIL 434
            |.|:.|.|..|:.||.|||.||:.:|:||:|..|...||.:|..:|.::.::.:.....|:.|::
  Rat   370 KAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEVI 434

  Fly   435 SNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFIAANNIDIYA-L 497
            :||.|.......|:::.|:||...:..|:|.|||:||..|.||: ||.| :.:...:::|:.. |
  Rat   435 NNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLR-PLGHNLPWYQYHSLDVIGFL 498

  Fly   498 IAVVLVILVLLLKLLLQFIYRKIFAKPKKEKKH 530
            :|.:.||..|.:|..| |||| .|||.:|:.|:
  Rat   499 LACLAVIAALAVKCFL-FIYR-FFAKKQKKMKN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	134/510 (26%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	146/535 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910