DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	135/558 - (24%)
Similarity:	254/558 - (45%)	Gaps:	78/558 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ATAICVL----GGCHGANILGVFTSL-----SPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNH 67
            |.||.:|    .||      |:.:.:     ..||.:...:..:.||.|||.|||:.....:::.
  Rat     7 AVAIFLLQLCWSGC------GICSKVLVWPCDMSHWLNLKTILEELAARGHEVTVLKYPSIIIDQ 65

  Fly    68 KNITVIM---VPL---TKEESQQMSDTIG-AMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDD 125
            ..:|.:.   :|:   |:.....:::.:. |::...|    ||:......::..|.::.|..:|.
  Rat    66 SKLTPLQFENIPVLYETEVAENHLNEIVNLAVNVIPN----LSLWEAARTLQDFFLQLTGNFEDL 126

  Fly   126 RVRDLY----LN--RDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGN---- 180
            ....||    :|  ||.|:|::                |..|||....:....|..|.:..
  Rat   127 CRSTLYNQTLMNKLRDAKYDVM----------------VLDPVIPCGELVAEVLQIPFVNTLRFS 175

  Fly   181 ------------PLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKEL 233
                        |:.::|||.:..  |....|:|.:|:.....|.|   |:|..|:.....:.:.
  Rat   176 MGYSMEKYCGQLPVPLSYVPVVMG--ELTDHMTFTERVKNMMLSLF---FEFWLQQYDFAFWDQF 235

  Fly   234 FGDDPNMP-EYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGN 297
            :......| .:.:.|....:....::...|.| ||.:|....:||:..|.. .|||:.:.||:.:
  Rat   236 YSKTLGRPTTFCKTVGKAEIWLIRTYWDIEFP-RPYLPNFEFVGGLHCKPA-KPLPKELEEFVQS 298

  Fly   298 ATD-GAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLE-KTPGKSDNIFYSKWLPQ 360
            :.: |.::.||||.:|  ::..:....:.:.|:::.|:|:|::...: .|.|.:..|.  .|:||
  Rat   299 SGEHGVVVFSLGSMIK--NLTEEKANLIASALAQIPQKVLWRYSGKKPATLGPNTRIL--NWIPQ 359

  Fly   361 DDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQP 425
            :|:|.||..:.||.|.|..||.||.|||.||:.:|:|||||.|...|..:|..:..::.::....
  Rat   360 NDLLGHPKTRAFITHGGTNGIYEAIYHGVPMVGIPMFGDQPYNIAHMEAKGAAVKVAINTMTSAD 424

  Fly   426 FKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAAN 490
            ...|:..:::.|.|.:.....|.::.|:|:...:..::|.|:|:||.||.||:.....:|:...:
  Rat   425 LLSALRAVINEPSYKENAMRLSRVHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYH 489

  Fly   491 NIDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKKEK 528
            ::|:...:.|.:|.|..::.....|:.||...:.:|:|
  Rat   490 SLDVIGFLLVCVVTLTFVITKCSLFMCRKCCLRERKKK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	126/518 (24%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	125/524 (24%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	73/242 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840