DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	143/549 - (26%)
Similarity:	262/549 - (47%)	Gaps:	40/549 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVHKSGIYLLLATAICVL--GGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVIT---- 59
            |..|.....||...||..  |.|  ..:|...|..  ||.|........||:|||.|||:.
  Rat     1 MSMKQTSVFLLIQLICYFRPGAC--GKVLVWPTEY--SHWINIKIILNELAQRGHEVTVLVSSAS 61

  Fly    60 -VLKPVVNHK-NITVIMVPLTKEESQ-QMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGA 121
             :::|..... |..:..|||:|.:.: ..:..|...::...:   ||:.....:|:.:|::.:..
  Rat    62 ILIEPTKESSINFEIYSVPLSKSDLEYSFAKWIDEWTRDFET---LSIWTYYSKMQKVFNEYSDV 123

  Fly   122 LKDDRVRDLYLNRD-------NKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIG 179
            : ::..:.|..|:.       ::||::|:.......:| .|:.:|.|::......|........|
  Rat   124 V-ENLCKALIWNKSLMKKLQGSQFDVILADAVGPCGEL-LAELLKTPLVYSLRFCPGYRCEKFSG 186

  Fly   180 N-PLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMP-E 242
            . ||..:|||.:..  |....|:|.:|:.......:   |||..|...::.:.:.:.|....| .
  Rat   187 GLPLPPSYVPVVLS--ELSDRMTFVERVKNMLQMLY---FDFWFQPFKEKSWSQFYSDVLGRPTT 246

  Fly   243 YSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATD-GAILLS 306
            .:|::....:....:....|.| .|.:|....:||:..|.. .|||:.|.||:.::.: |.::.|
  Rat   247 LTEMMGKADIWLIRTFWDLEFP-HPFLPNFDFVGGLHCKPA-KPLPREMEEFVQSSGEHGVVVFS 309

  Fly   307 LGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLE-KTPGKSDNIFYSKWLPQDDILAHPNIK 370
            |||.||  ::..:....:.:.|:::.|:|:|:::..: .|.|.:..::  ||:||:|:|.||..|
  Rat   310 LGSMVK--NLTEEKANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLY--KWIPQNDLLGHPKTK 370

  Fly   371 LFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILS 435
            .|:.|.|..||.||.|||.|::.:|:|.|||.|.:.||.:|..:......|.......|:..:::
  Rat   371 AFVAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMN 435

  Fly   436 NPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAV 500
            :|.|.:.....|.::.|:|:...:..::|.|||:||.||.||:|.|..:|:...:::|:...:.:
  Rat   436 DPSYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLLL 500

  Fly   501 VLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            .:|.:|.::.....|..||.....||:|:
  Rat   501 CVVGVVFIITKFCLFCCRKTANMGKKKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	132/501 (26%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	133/520 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910