DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	554	Identity:	144/554 - (25%)
Similarity:	254/554 - (45%)	Gaps:	99/554 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHN-VTVITVLKPVVNHKNIT 71
            ::||.:|:   |....|.|:.|...:..|||.|..:.|..|.||||: |.:::..:.:....:.:
Mouse     8 FMLLWSAV---GIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLSEGRDIAPSNHYS 69

  Fly    72 VIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDLYLN--- 133
            :...|             |..:.|.:...:.|.:|.      :|.....|::...:.|.|..
Mouse    70 LQRYP-------------GIFNSTTSDAFLQSKMRN------IFSGRLTAVELVDILDHYTKNCD 115

  Fly   134 ------------RDNKFDLVL------SGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGN 180
                        :..||||:|      .| |:..:.||    ||..|.......|.:     :|.
Mouse   116 MMVGNQALIQGLKKEKFDLLLVDPNDMCG-FVIAHLLG----VKYAVFSTGLWYPAE-----VGA 170

  Fly   181 PLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGIF-------DFVTQRRSKRLYKELFGDDP 238
            |..:||||..:..:.  ..|:|.:|:..      .|::       .|:...:.:|:
Mouse   171 PAPLAYVPEFNSLLT--DRMNFLERMKN------TGVYLISRIGVSFLVLPKYERI--------- 218

  Fly   239 NMPEYS--------ELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL 295
             |.:|:        :||..:||....:....|.| ||.:|..:.:|||..|.. .|||:::..::
Mouse   219 -MQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFP-RPTLPNVVYVGGILTKPA-SPLPEDLQRWV 280

  Fly   296 GNATD-GAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLP 359
            ..|.: |.:|:|.|:.||  :::.|...|:...|.:|.|:|||::.. .|.....:|....:|||
Mouse   281 SGAQEHGFVLVSFGAGVK--YLSEDIANKLAGALGRLPQKVIWRFSG-TKPKNLGNNTKLIEWLP 342

  Fly   360 QDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVK---QGFGLTQSLLSL 421
            |:|:|.|.||:.|::|.|...|.|..|||.|::.:|:|||   :.|.|.:   :|.|:.....::
Mouse   343 QNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGD---HYDTMTRVQAKGMGILLEWNTV 404

  Fly   422 EEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSF 486
            .|....:|::::::||.|..:....|.:::|:|........||.:|::||.||.||:|.:..:||
Mouse   405 TEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISF 469

  Fly   487 IAANNIDIYALIAVVLVILVLLLKLLLQFIYRKI 520
            .....:||..::.:..|:|..:|..:.:||||||
Mouse   470 CQYFLLDIAFVLLLGAVLLYFILSYVTKFIYRKI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	133/522 (25%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	137/535 (26%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840