DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-54

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_501996.2	Gene:	ugt-54 / 188885	WormBaseID:	WBGene00012013	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	144/573 - (25%)
Similarity:	229/573 - (39%)	Gaps:	102/573 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNV-TVITVLKPVVN--- 66
            |..:|...|.|:       |||...:.::.||:....:..|||.:|||.| .||..|..:|.
Worm     6 GFLILPGFANCL-------NILFYVSVIAQSHIPFHNTAIKVLLDRGHTVDLVIAQLNEMVKLKF 63

  Fly    67 ----HKNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFM-FDKMAGALKDDR 126
                .||.|     ...|:........|.:|.       :.:.:.:...||: ||.|...|.:..
Worm    64 PNGVGKNYT-----FGYEDPNFYRKNAGHLSD-------IFVEKPIPMAEFLTFDDMTFNLCETV 116

  Fly   127 VRD----LYLNRDNKFDLVLSGYF-----MNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPL 182
            |:|    .|:.:.| :|:.||..:     :.::..|...|        |:|.|..|..|.|.:
Worm   117 VKDPNLLNYIKQGN-YDIGLSSDYDPCANILMHAGGVPSK--------ASMVPTPLFQPQIVS-- 170

  Fly   183 EIAYVP---SISDSVEKGKGMSFRQRLAGYSSSFFFGIFD---------FVTQR---RSKRLYKE 232
              |.:|   |:..:|...||          ..|||..:|.         ||..|   :...|..|
Worm   171 --AGLPSPASVYGTVLYPKG----------DDSFFNRLFHLIRHTYNIYFVAPRLMEKYNNLLLE 223

  Fly   233 LFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGN 297
            .||  |..|...|:.:|..:|...|:...|.| ||.......|||:. |....||.:...:.|..
Worm   224 TFG--PTFPSAEEIERNVDIILVNSNEIIEKP-RPVSHKIKYIGGMG-KKKAQPLNKEFNDILAT 284

  Fly   298 ATDGAILLSLGSNVKGSHI------NPDTVVKMFNVLSKLKQRVIWKWEDLEKTP---GKSDNIF 353
            :..|.:|.|.|:.|..|.:      |..|..|.|...|     .:||:::|....   ..|.||.
Worm   285 SNKGVVLFSFGTQVATSKVPIEIRKNFVTAFKHFPDFS-----FLWKYDNLTDDAELFADSSNIH 344

  Fly   354 YSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSL 418
            ..:||||.|:|....:|.||:|.|.....|....|.|:|::|:|.||..||...|.:..|:....
Worm   345 RVEWLPQTDLLGDNRVKAFISHMGLNSFLETSAAGIPVLAVPLFIDQQHNALNAVSRDIGVIVER 409

  Fly   419 LSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQS-PLV 482
            ..|..:....|:.::|.||:|.:.....|.:..::|..:....:.|.||..::.|...:.: |..
Worm   410 HQLTVENLVNALQKLLYNPKYGENAKMISKMMNEKPEQSERLFVDWVEYAAKNPGLHKIMNLPGA 474

  Fly   483 HMSFIAANNIDIYALIAVVLVILVLLLKLLLQFI--------YRKIFAKPKKE 527
            .::.....::|:..::.:.|...::::...|.||        .|.|..|.|.|
Worm   475 ELTPFWYYSVDVILIVVLSLTSSLIIIWKTLSFIKCQISIRSVRSIEPKSKSE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	133/524 (25%)
ugt-54	NP_501996.2	UDPGT	35..507	CDD:278624	128/515 (25%)
ugt-54	NP_501996.2	egt	<218..498	CDD:223071	76/288 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910