DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-30

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_506729.1	Gene:	ugt-30 / 187955	WormBaseID:	WBGene00011340	Length:	535	Species:	Caenorhabditis elegans

Alignment Length:	572	Identity:	150/572 - (26%)
Similarity:	248/572 - (43%)	Gaps:	87/572 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVN----- 66
            :||......|:|...:..|||....:.:.||.......|..|.||||||   |.|.||||
Worm     2 LYLQSIIFFCLLLYSNCLNILVYAPAFAASHSKFLGKLADTLTERGHNV---TYLMPVVNIAKRD 63

  Fly    67 -------HKNITVIMVPLTKEESQQMSDTIG---------AMSKTDNSNMILSMLRMMGQMEFMF 115
                   .|:: ||:....|..||:.:||..         ....:.||..|         .:|..
Worm    64 ECKGVKITKDV-VIVEAGEKMLSQKQADTPNDEILDVWWTVQMDSSNSREI---------FQFFC 118

  Fly   116 DKMAGALKDDRVRDLYLNRDNKF-DLVLSGYFMNVYQ------LGFAKKVKAPVIVVATMPP-NQ 172
            ..|..|.::      :|:|.:.| |:....:.:.:.:      |||.|.:.....::|:... ..
Worm   119 SDMKIACEN------FLSRRDIFEDMKARNFDLAILEPVSACGLGFVKALGIEKTILASSSVFYD 177

  Fly   173 LLNPLIGNPLEIAYVPSISDSVEKGKGMSFRQRLAGYS-----SSFFFGIFDFVTQRRSKRLYKE 232
            ::.|.||.||:.:|||| ..|| .|:.:|..::...:.     |....|:||     ....:|:.
Worm   178 VILPYIGEPLDYSYVPS-GYSV-TGQELSLGEKFENWMVSREISIALEGLFD-----GEMEIYRR 235

  Fly   233 LFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVK---DTPDPLPQNMAEF 294
            |.|.  |:..:..|..:.|:.|..|:...:.| ||.:...:.||||.|.   ...|.|.:...:.
Worm   236 LLGH--NLTNWRHLFPSASIFFVNSNPFFDFP-RPVLEKTVPIGGISVNMGVRKEDMLTEEWEKV 297

  Fly   295 LGNATDGAILLSLGSNVKGSHINP---DTVVKMFNVLSKLKQRVIWKWE-DLEKTPGKSDNIFYS 355
            | |.....:|:|.|:.|..:|:..   ..:::.|.....:  ..|||:| |........|||::|
Worm   298 L-NQRPHTMLVSFGTLVMSTHMPKKWRSGLLEAFKSFPNV--TFIWKYESDDHSFANGIDNIYFS 359

  Fly   356 KWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQ--GFGLTQSL 418
            ||:||:::|....:..|::|.|.|.|.|..:.|||.|.:|||.||..||:.:.:.  ...|.:|.
Worm   360 KWVPQNELLNDNRLTAFLSHGGLGSIMELAFSGKPALIIPVFADQTRNANTLARHRGAICLHKSQ 424

  Fly   419 LSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH 483
            :. ..:..|:|...:|.:..:.:.....::..|::|...::::|.:||:|........:.....|
Worm   425 MK-NTEVLKKAFKSVLFDASFKNNSLKLAATLRNQPNKPKDTLIKYTEFVGEFGPFPQMDPYGRH 488

  Fly   484 MSFIAANNIDIYALIAVVLVILVLLL-----KLLLQFIYRKIFAKPKKEKKH 530
            ::....:.||||.||.||..|.|.|:     ||:..||      |.|..:|:
Worm   489 LNVFQKSFIDIYTLIIVVSSIFVALIFNVIAKLIQYFI------KSKSSEKN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	132/524 (25%)
ugt-30	NP_506729.1	UDPGT	21..529	CDD:278624	143/546 (26%)
ugt-30	NP_506729.1	Glycosyltransferase_GTB_type	<255..524	CDD:299143	76/273 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910