DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-13

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504317.2	Gene:	ugt-13 / 186766	WormBaseID:	WBGene00019232	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	149/555 - (26%)
Similarity:	257/555 - (46%)	Gaps:	79/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVHKSGIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVIT---VLK 62
            |..|..:|.||.:.:      ...|||........||:......|:::|..|||||:..   :..
Worm     1 MYFKLALYCLLISFV------SSKNILIYDPIFGFSHVKFVSLMAEIIANHGHNVTLFRPYHIAL 59

  Fly    63 P----VVNHKNITVI-MVP-----LTKEESQQM----SDTIGAMSKTDNSNMILSMLRMMGQMEF 113
            |    :|.:|||.:| ..|     |...|.|..    :|.:  :|:....::::|.| :.|:|:.
Worm    60 PNVDGLVKNKNIQIIDYFPKHYDELLHAEKQTFPGFWNDPL--ISQPVLRSLVVSKL-ISGEMKR 121

  Fly   114 MFDKMAGALKDDRVRDLYLN--RDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLN- 175
            ...::   |:|:||    ||  |..|||:|:|..| .:..|..|..:..|.|.:  ||..:.|:
Worm   122 TATQL---LQDERV----LNELRSKKFDVVISETF-EITGLYLAHIIDVPCIPM--MPAVRYLDL 176

  Fly   176 -PLIGNPLEIAYV--PSISDSVEKGKGMSFRQRLAGYSSSFFFGI-FDFVTQRRSKRLYKELFGD 236
             .|:|.|..|.|.  |....:.|.|    |..||......||... .|:.:|.::..:...:
Worm   177 GYLLGQPSLIGYAQQPGSKMAPEAG----FLDRLNDVYQYFFMSCETDWTSQYQNDNIEAAI--- 234

  Fly   237 DPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMA------EFL 295
            ...:|.:.:|::|:.:....|:...:..: |.....:::||:.| |...  .:|:|      |.:
Worm   235 GRPLPNWKDLLRNSPIYILNSNPYLDFAV-PTTATIVQVGGMTV-DLKK--MKNVAKLSEEYETI 295

  Fly   296 GNATDGAILLSLGSNVKGSHINPDT----VVKMFNVLSKLKQRVIWKWE--DLEKTPGKSDNIFY 354
            ....|.|:|:|.||.::...: ||.    ::|:|..||.:  ..|||:|  |:|.......|:..
Worm   296 LAERDYAVLISFGSVIRSFQM-PDNFKVGLIKLFESLSDV--TFIWKYEKGDVEFQKRLPKNVHL 357

  Fly   355 SKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLL 419
            .||:||..:||...:|||:.|.|.|..||..|.|||.|.:|:|||||.|||::.:.|..:..|..
Worm   358 KKWVPQPSLLADKRVKLFVTHGGLGSTTEVAYTGKPALMVPIFGDQPNNADMLARHGGAIAYSKF 422

  Fly   420 SLEE-QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIR--HHGAAHLQSPL 481
            .|.. :.....:.:::.||:|.:|......:..::|:..:|:.|...|:.::  :|.:   |.|.
Worm   423 DLANGEKLANTVKDMVFNPKYKEKAELLFDVLSNQPIDPKENFIKHLEFAMKFPNHRS---QVPA 484

  Fly   482 VHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFI 516
            |:.:.:.|.    |.|..:|..:::.|:...|.|:
Worm   485 VNQAGLIAQ----YYLDVIVFFVMISLISSYLSFV 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	140/520 (27%)
ugt-13	NP_504317.2	egt	1..509	CDD:223071	147/547 (27%)
ugt-13	NP_504317.2	UDPGT	29..514	CDD:278624	140/518 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960