DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-42

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_503278.2	Gene:	ugt-42 / 185168	WormBaseID:	WBGene00017959	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	138/565 - (24%)
Similarity:	234/565 - (41%)	Gaps:	87/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHK--NIT 71
            |:|...:.::....|.|.|.|..:...||.......|..|.|.||||||:::   :|:.|  ||:
Worm     4 LILLIFVFLISNISGFNYLVVSPAFGHSHSTFMGKLADALTEAGHNVTVLSI---IVSSKFRNIS 65

  Fly    72 -------VIMVPLTKEESQQMSD-----------TIGAMSKTDNSNMILSMLRMMG--------- 109
                   :::|..|.|:.||..:           ..|.:.:|..|.::.:.:...|
Worm    66 YTKLTKDIVVVETTNEQDQQAENMENNDFSRYWTQEGTLLETIPSYLMFTKMSDHGYETFRNHAL 130

  Fly   110 -QMEFMFDKMAGALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFA--KKVKAPVIV-VATMPP 170
             |||:        ||..|.|         :|.|   :|.:....|.|  :.::.||.: |.::..
Worm   131 PQMEY--------LKSHRPR---------YDAV---FFESYLHTGKAIQEYLEIPVFLPVTSLTH 175

  Fly   171 NQLLNPLIGNPLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFG 235
            :..|..|||.|:..:|:.....:.  |..|:|::|:....|.:...|  .::....|.|
Worm   176 DYRLAELIGEPVSPSYLSGYFTNF--GNIMNFQERVINTLSYYLAQI--LISSPNWKTL------ 230

  Fly   236 DDPNM-----PEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL 295
            .||:.     .||    .....:|..|:...:.| ||.:...||||||.|  ..|.|.....:..
Worm   231 QDPSKDLLVESEY----YRAPYVFINSNPYIDFP-RPLLSKTIEIGGITV--DADALKSEKVDET 288

  Fly   296 GN----ATDGAILLSLGSNVKGSHINPDTVV-KMFNVLSKLKQ-RVIWKWEDLEKT-PGKSDNIF 353
            .|    .....:|:|.|:..|..|: ||:.. .|..|:...|. ..|||:|..|.: ...::||.
Worm   289 WNNILKRRPHNVLISFGTMFKSIHM-PDSYKNNMVKVMKSFKNVTFIWKYESEETSFANGAENII 352

  Fly   354 YSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSL 418
            :.||.||..:||...:..|..|.|.|.:.|..|.|||.|..|:|.||..|:.::.:....:..|.
Worm   353 FKKWTPQTALLADSRLSAFFTHGGLGSVNELSYLGKPALLCPLFADQVRNSKMLSRHNGSIEISK 417

  Fly   419 LSLEE-QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLV 482
            .:||. ...:.|:..||.:..|.:.....:.....:|...:|..:...|:..|......|...|.
Worm   418 FNLESYNTLRSALHSILFDESYAENAEKLAKKLEFQPAKPKELFVRHAEFAARFGEQPALDCNLR 482

  Fly   483 HMSFIAANNIDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKKE 527
            .|.|...:.:|:...:...:|:::|.|.::::.|.:.:..|.|::
Worm   483 TMGFATYHLLDVVVCLTSFVVLVILSLVVIIRKIVQSLAIKMKRD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	131/526 (25%)
ugt-42	NP_503278.2	Glycosyltransferase_GTB_type	14..501	CDD:299143	130/527 (25%)
ugt-42	NP_503278.2	UDPGT	22..495	CDD:278624	128/513 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910