DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-38

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504812.1	Gene:	ugt-38 / 184294	WormBaseID:	WBGene00017333	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	142/552 - (25%)
Similarity:	240/552 - (43%)	Gaps:	63/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLATAICVLGGCHGANILGVFTSL-SPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHK---- 68
            ||||....:.......|.| ||..| :.||.....:.|..|.:.||||...|   |::..|
Worm     2 LLLALLFTLYANVSSFNFL-VFCPLFAHSHSKFFATIADSLTDAGHNVAFFT---PIIVEKYRNF 62

  Fly    69 NIT------VIMVP--LTKEESQQMS--DTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALK 123
            |.|      |.|.|  ..||..:|||  |.:...::...:..|::::|:   .:.|:::....:|
Worm    63 NYTKSTKDVVYMEPSKKLKEYGRQMSTGDFVRYWTEDSTATEIITVVRI---FQKMYNEQGTVMK 124

  Fly   124 D--DRVRDLYLNRDNKFDLVL-SGYFMNVYQLGFAKKVKAPVIVVA-TMPPNQLLNPLIGNPLEI 184
            |  :.:.||   :..|||::: ..:..:.|.|  ...::.|..:.: ::..:..|...||.|:
Worm   125 DNIEILNDL---KKRKFDVIIFEAFIFSAYPL--MDYLEIPTFIPSLSVAHDTALAVEIGEPV-- 182

  Fly   185 AYVPS-ISDSVEK-GKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELV 247
              :|| :||.:.. |..:|..:|.   .::|....|||:....:.|.:|..:    |..:...:|
Worm   183 --MPSVVSDCLSPFGDKLSITERA---FNAFMVPYFDFMIGYPTHRSFKPPY----NPIDIRSIV 238

  Fly   248 KNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDT---PDPLPQNMAEFLGNATDGAILLSLGS 309
            ...|.:|..|:...:.| ||.:...|:||||.|...   ...|.:..:|.| ...:..:|:|.||
Worm   239 PEASFVFLNSNPFVDFP-RPTLTKTIQIGGISVDSNELRSQKLDETWSEIL-KLREKTMLVSFGS 301

  Fly   310 NVKGSHINPDTVVKMFNVLSKLKQ-RVIWKWEDLEKTPGKSD-------NIFYSKWLPQDDILAH 366
            .:....:.....:.:.|.:.|.|. ..|||:||     ..||       ||.::||:||..:||.
Worm   302 MLYSKDMPFKNKIALKNAMEKFKNVTFIWKYED-----DSSDEFAKGIENIHFAKWVPQTALLAD 361

  Fly   367 PNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSL-EEQPFKEAI 430
            ..:..|:.|||.|.|||..|.|||.:..|...||..|..::|:....:..|...| :.:...||.
Worm   362 SRLSAFLTHAGLGSITELSYLGKPAILCPQLFDQMRNTKMLVRHNGSIELSKYDLGKSEKIIEAF 426

  Fly   431 LEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIY 495
            ..||.:..|.......:....::|:..:|.::...||..|......|......|||:....:|:.
Worm   427 QAILFDSSYAKNAQKLAEQLENQPIKPKEMMVKHAEYAARFGRLPSLDPYSRKMSFVEYFLLDVA 491

  Fly   496 ALIAVVLVILVLLLKLLLQFIYRKIFAKPKKE 527
            |:...:|..:|.::..|:|.::.....|.|.|
Worm   492 AICVFILTFVVFVVTKLVQSLFDIFLIKRKTE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	133/513 (26%)
ugt-38	NP_504812.1	Glycosyltransferase_GTB_type	12..512	CDD:299143	135/529 (26%)
ugt-38	NP_504812.1	UDPGT	29..521	CDD:278624	131/520 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910