DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-37

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504811.2	Gene:	ugt-37 / 184293	WormBaseID:	WBGene00017332	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	130/543 - (23%)
Similarity:	235/543 - (43%)	Gaps:	71/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ICVLGGCHGANILGVFTSLSP----SHLIIQMSTAKVLAERGHNVTVI--TVLKP-----VVNHK 68
            :.:|..|...|....|...||    ||.......|..|:|.|||||..  |:::.     .|.|.
Worm     4 LILLFACFNVNFSYNFLIFSPLFGHSHTTFFAKIADTLSEAGHNVTFFTPTIIRKFSKINYVKHT 68

  Fly    69 NITVIMVPLTKEE--SQQMSDTIGAMSKTDNSNM--ILSMLRMMGQMEFMFDKMAGALKD--DRV 127
            ...:.:.|..|.|  ..||.|...:...||:|:|  :..|:::..:   ||.:.|..|..  |.:
Worm    69 KHVIHLEPSEKLERYGNQMEDVDISRFWTDDSSMAEMFPMIKLFNE---MFAEQAFVLGQNLDVL 130

  Fly   128 RDLYLNRDNKFDLVLSGYFMN-VYQLGFAKKVKAPVIVVAT---MPPNQLLNPLIGNPLEIAYVP 188
            .:|   ::.|||:::...|.. .|.|  .:.::....:.::   ..||.|::  ||.|...:.||
Worm   131 DEL---KEMKFDVMIFERFAECAYPL--LEYLEIETFIPSSSLLFDPNLLIS--IGEPRIPSTVP 188

  Fly   189 -SISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSEL----VK 248
             .:|...:|   |:..:||.   ::....||..:......:.::         |.|..:    ::
Worm   189 LPMSKFTDK---MTMTERLL---NAIAVPIFHSLLPTHEFKSFR---------PPYQAIDIQKME 238

  Fly   249 NTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATD---GAILLSLGSN 310
            :.|....::..|.....||.:...::||||.| |..:.....:.|......|   ..||:|.||.
Worm   239 HLSSFILSNSNPYIDYPRPTLEKNVQIGGISV-DVENLKIHKVNEEWDRILDMRQKTILVSFGSV 302

  Fly   311 VKGSHINPDTVVKMFNVLSK-LKQ----RVIWKWE--DLEKTPGKSDNIFYSKWLPQDDILAHPN 368
            :    ::.|..|:...:|:| :||    ..|||:|  |.:....:::||.:|.|:||..:||...
Worm   303 M----LSKDMPVENKKILAKTMKQFPEVTFIWKYEFNDTDLFASETENIHFSSWVPQTALLADRR 363

  Fly   369 IKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSL-EEQPFKEAILE 432
            :..|..|||.|.:.|..|.|||.:..|:|.||..||.::.:....:..|...| ..:..::.:..
Worm   364 LTAFFTHAGLGSVNEVSYLGKPSIMCPIFADQMRNAKMLARHNGSIEISKYDLGNGEKIEKTLRT 428

  Fly   433 ILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYAL 497
            ||.:..|.......:....::|:..:|.::...|:..:......|......:||:....||:.|:
Worm   429 ILFDDSYRLSAEKLAHQLANQPVKPKELLLRHAEFAAQFGRLPSLDPYSRQLSFVEYFLIDVAAI 493

  Fly   498 I----AVVLVILVLLLKLLLQFI 516
            :    .:::|:|..::|.|:.|:
Worm   494 LIFSSLLIVVVLFQIIKRLINFL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	122/511 (24%)
ugt-37	NP_504811.2	Glycosyltransferase_GTB_type	1..504	CDD:299143	125/529 (24%)
ugt-37	NP_504811.2	UDPGT	37..510	CDD:278624	119/502 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910