DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-50

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_741913.1	Gene:	ugt-50 / 181413	WormBaseID:	WBGene00011564	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	539	Identity:	122/539 - (22%)
Similarity:	232/539 - (43%)	Gaps:	62/539 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CVLGGCHG------ANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITV---LKPVVNHKNIT 71
            |:....||      |.||....|:|.||:::....|.:|...||: ||:.:   .|.:.|:....
Worm    12 CLTALLHGSFIVNAAKILVYCPSISKSHVLLCSKYADLLHNAGHD-TVLFIPSYSKLLDNYDGAK 75

  Fly    72 VIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVRDLYLNRDN 136
            ...|......::.....:|.::....::.|..:.|:....:|..|..|..|  .::.::....|.
Worm    76 HAKVWRLHNVTEAYDTKLGTLANVMENSHIGFIDRLTFDADFWIDMCADLL--GKLPEMQHIIDY 138

  Fly   137 KFDLVLSGYFMNVYQLGFAKKVKAPVIV-VATMPPNQLLNP---------LIGNPLEIAYVPSIS 191
            |||||:....          ....|.|| :..:|...||:.         .:|.|...:||||:.
Worm   139 KFDLVIYNEI----------DPCTPAIVRLFNIPKTVLLSSEAIMDKVAWNLGLPTLPSYVPSVE 193

  Fly   192 DSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFFA 256
            ::....: |||.:|::.....|...:..::.......|:::....|  .|..:|:::|.||:...
Worm   194 ENPNHDR-MSFFERMSNVYKFFQSIVVHYLQDIHVLNLFRKEVSSD--FPSIAEIIRNVSLVLVN 255

  Fly   257 SHAPSEGPIRPNVPAAIEIGGIQV-KDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGSHINPDT 320
            :....:.| |......:.:|.::. ||....||:...::......|::.:|.|:......:....
Worm   256 TDEIFDLP-RSYSSKFVYVGMLEAGKDENVTLPKKQDDYFKKGKSGSVFVSFGTVTPFRSLPERI 319

  Fly   321 VVKMFNVLSKLKQRVIWKWEDLEKTPGKSD----------NIFYSKWLPQDDILAHPNIKLFINH 375
            .:.:.|.:.||..     :..:.||....:          |:....|:||..:|.|.|:|||::|
Worm   320 QLSILNAIQKLPD-----YHFVVKTTADDESSAQFFSTVQNVDLVDWVPQKAVLRHANLKLFVSH 379

  Fly   376 AGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYF 440
            .|...:.|..|:|.||:.:|||.||..|...:.::|.|......::.::.|.:||..:|....|.
Worm   380 GGMNSVLETMYYGVPMVIMPVFTDQFRNGRNVERRGAGKMVLRETVVKETFFDAIHSVLEEKSYS 444

  Fly   441 DKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVIL 505
            ..|...|.|.:::|.::.|.|..|.::|:::..:.|......::|.|..|::|::..:.::
Worm   445 SSVKRISHLMKNKPFTSEERVTKWIDFVLKYETSEHFDLESNNLSIIEHNHLDLFFYLCII---- 505

  Fly   506 VLLLKLLLQF-IYRKIFAK 523
                 .||.| :|||||.:
Worm   506 -----SLLNFVVYRKIFKR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	112/503 (22%)
ugt-50	NP_741913.1	egt	9..475	CDD:223071	109/484 (23%)
ugt-50	NP_741913.1	UDPGT	26..520	CDD:278624	119/525 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910