DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-46

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_508112.1	Gene:	ugt-46 / 180404	WormBaseID:	WBGene00015141	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	127/535 - (23%)
Similarity:	231/535 - (43%)	Gaps:	52/535 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITV----LKPVVNH 67
            |::||||.:   .......||....:.|.||||.....|..||..||:|||:.:    :....|.
Worm     4 IFVLLATFV---NAAFSYKILVFSPATSKSHLISNGRLADELARAGHDVTVLELDFLGISQTTNS 65

  Fly    68 KNITVIMVPLTKEESQQMSDTIGAMSKT--DNSNMILSMLRMMGQMEFMFDKMAGALK-DDRVRD 129
            ..:....:....:||....:.:...|:|  :..:....:...........|..|..|| ||...:
Worm    66 VKVAKKRIIDGFQESTNFKNVLHGFSETVMEEPSFTDEIKGWWAYQNVYNDLCAEFLKMDDIFNE 130

  Fly   130 LYLNRDNKFDLVLSGYF---MNVYQLGFAKKVKAP-VIVVATMPPNQLLNPLIGNPLEIAYVPSI 190
            |   ::.|||    |:|   :|:...|:|..::.| ..::::.|....:....|.|:..:.|...
Worm   131 L---KNAKFD----GFFAEQINLCGFGYAHALEIPRHFLISSCPFAAPVYDFTGLPMPTSTVAFA 188

  Fly   191 SDSVEKGKGMSFRQRLAGYSSSFFFGI---FDF-VTQRRSKRLYKELFGDDPNMPEYSELVKNTS 251
            :|       :|........:.:.|..:   .:| :...|.:..::..||:  :.|....:..:..
Worm   189 AD-------LSISPTYTERARNLFVAVLTKLEFTLLNNRLQAHFQHKFGE--HFPSLYSVTSDVD 244

  Fly   252 LIFFASH--APSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGS 314
            :||.|:.  .........|:   :.:||:.|.|....:....|..:....:|.|..|||:....:
Worm   245 VIFVATDEIIDISTTTLQNI---VHVGGLGVDDDVAEMDNVFASEMSKGKEGVIYFSLGTIANTT 306

  Fly   315 HINPDTVVKMFNVLSKLKQR--VIW--KWEDLEKTPGKS-DNIFYSKWLPQDDILAHPNIKLFIN 374
            .|:...:..:.:::.|....  ||.  |::...:...|| .|.|.|.||||..||.||.:||||.
Worm   307 KIDSKVMRTVLDIVKKFPDYHFVIRADKYDLSTREYAKSVSNAFVSDWLPQPAILHHPRLKLFIT 371

  Fly   375 HAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLT--QSLLSLEEQPFKEAILEILSNP 437
            |:|...|.||...|.|::::|...||..|:..:.|:|:|:.  :..|..|.:..::||.||:.|.
Worm   372 HSGYNSIVEAARAGVPLINIPFMFDQNLNSRAVEKKGWGIRRHKKQLLTEPEEIEKAISEIIHNK 436

  Fly   438 QYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVL 502
            :|..|......|.:.:|:|:.:.:|..||:.|::||...::......:.....|:|      |::
Worm   437 KYSLKAQRIRDLIKSKPLSSSQLLIKTTEWAIKNHGLDEIKFESRGQTTWTYYNLD------VII 495

  Fly   503 VILVLLLKLLLQFIY 517
            .:..|.:.|::..|:
Worm   496 PVFWLSISLVIPTIF 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	120/505 (24%)
ugt-46	NP_508112.1	UDPGT	19..527	CDD:278624	122/517 (24%)
ugt-46	NP_508112.1	egt	<213..503	CDD:223071	77/300 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910