DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-4

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001041203.1	Gene:	ugt-4 / 179754	WormBaseID:	WBGene00013905	Length:	535	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	121/556 - (21%)
Similarity:	224/556 - (40%)	Gaps:	83/556 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LATAICVLGGCHGANILGVFTS---------LSP----SHLIIQMSTAKVLAERGHNVTVIT--V 60
            ::..:|||       :..|..|         :||    ||:......|..||:.||.||...  |
Worm     1 MSRVLCVL-------LFSVLVSHVESYKFLVISPVYGYSHMKFMAIIANQLADEGHQVTYFQPFV 58

  Fly    61 LKPVVNHKNITVIMVPLTK----EESQQ----MSDTIGAMSKTDNSNMILSMLRM----MGQMEF 113
            ::..::||.:...::.:..    ||.::    .:|...|...:...:.:.::..|    :...|.
Worm    59 IEAYLDHKLLNNSLIDVINYWHDEEGRRHIPPSNDLHDAWYSSKYQSALSAVFDMPQFLVSAWEH 123

  Fly   114 MFDKMAGALKDDRVRDLYLNRDNKFDLVLSGY--FMNVYQLGFAKKVKAPVIVVATMPPNQLL-- 174
            |..|:   .:|..:..:.  :|..||:|::..  |..:|...:.:...    :|:....::|:
Worm   124 MCRKI---FQDSELHKIL--KDKDFDVVIAETFDFCGLYLADYIQSKS----IVSVFTGSRLIAI 179

  Fly   175 -NPLIGNPLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFG-----IFDFVTQRRSKRLYKEL 233
             :|| |.|..:.|:|:.| |...|...|...|:......:.||     |||:...:.::..:.:
Worm   180 TDPL-GEPSSLHYIPAPS-SDNFGSSASIFDRINDLYHKYVFGSGYSIIFDWQYNQIARLTHGK- 241

  Fly   234 FGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQV-KDTPDPLPQNMAEFLGN 297
                  :..:.:::|:.: ..||:..|......|.:...|.|||..: |.....:|......| |
Worm   242 ------VRHWKKILKDVT-YHFANSNPYLDFAAPTISKVIPIGGYDMDKSIQTKIPDEFDSIL-N 298

  Fly   298 ATDGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRV--IWKWED------LEKTPGKSDNIFY 354
            .....:.:|.||.||...:.......|..:.:...|.:  :||:||      ..:.|   .|:..
Worm   299 ERSLTVYVSFGSMVKAKFMPESYKEAMLRMFTANTQNITFLWKYEDPTDIFFKNRLP---KNVIL 360

  Fly   355 SKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLL 419
            ..|.||..:||...:||||.|.|.|...|..|..||.:.:|:..:||.|..::.:.|   :..:.
Worm   361 KDWFPQRALLADKRVKLFITHGGLGSTMELAYAAKPAIVIPLIAEQPDNGKMLARHG---SAEIY 422

  Fly   420 SLEEQPFKE----AILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSP 480
            |..:.|..|    .:.::|.:..|.......:.:..::|:..||.:|..:|..........|...
Worm   423 SKHDIPHWEKLNRLLQKMLQHSSYQKAADRLARVLSNQPIKPRELMIKHSEMAAMFGKMPELTPS 487

  Fly   481 LVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFI 516
            :..||.|...|:||..|..::.:...:||...|.|:
Worm   488 VQDMSIIEFYNLDIIFLFLIISIGTSVLLWKFLYFV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	113/528 (21%)
ugt-4	NP_001041203.1	egt	1..473	CDD:223071	108/504 (21%)
ugt-4	NP_001041203.1	UDPGT	21..500	CDD:278624	109/504 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960