DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-2

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_505672.2	Gene:	ugt-2 / 179450	WormBaseID:	WBGene00007073	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	155/562 - (27%)
Similarity:	265/562 - (47%)	Gaps:	81/562 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVI-TVLKP------V 64
            ::|..|....||    ..|.|.|......||:......|..||...||||:: |.:..      :
Worm     7 VFLFFALYCNVL----AYNYLVVAPVFGYSHMKFMNKVADTLANGKHNVTLLQTYIYEHWGKIRI 67

  Fly    65 VNHKNITVI------MVPLTKE---------ESQQMSDTI-GAMSKTDNSNMILSMLRMMGQMEF 113
            |.:|||.:|      .||..::         :::.:::.| |||:         .|..:..:.:.
Worm    68 VKNKNIEIIDYHNSENVPSNEQSASAFKFFWDNEIVNNPITGAMA---------PMFILYNEFKP 123

  Fly   114 MFDKMAGALKDDRVRDLYLNRDNKFDLVLSGY------FMNVYQLGFAKKVKAPVI-VVATMPPN 171
            |.|::   |.|..:....|:  ||||    ||      |.::|.....|....|:. .:..:|.:
Worm   124 MCDRI---LTDKELHQWILS--NKFD----GYVAESFDFCSLYLGDHLKLNLLPMFSTIKNVPGS 179

  Fly   172 QLLNPLIGNPLEIAYVPSISDSVEKGKGMSFR-QRLAGYSSSFFFGIFDFVTQRRSKRLYKELFG 235
            .    .||.|..:.|.||:..:....:.:..| |.:..::|  |...|..:.:|:.::.|..|.|
Worm   180 H----AIGEPSLLNYAPSLYTNFGSDQTVWDRIQDITAFTS--FHYAFSNLFERQYRQAYDLLNG 238

  Fly   236 DDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEF--LGNA 298
            |   :..:.|::: |:..||.::.|..|...|.:..::||||..: |.|..|..| .||  |.:.
Worm   239 D---VRTWREILQ-TATYFFYNNNPYIGFAMPTLEKSVEIGGFTI-DPPHDLSLN-EEFDKLLDL 297

  Fly   299 TDGAILLSLGSNVKGSHINPDT----VVKMFNVLSKLKQRV-IWKW--EDLEKTPGKSDNIFYSK 356
            ....:|:|.|:.|:.:.: |:.    ::|||   :||.... |||:  ||.|.:...|:|:|..|
Worm   298 RKSTVLISFGTVVQSADM-PENFKSGLIKMF---AKLPDTTFIWKYEVEDAEFSKTLSENVFLKK 358

  Fly   357 WLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSL 421
            |:||..:||.|.:.|||.|.|.|...|..|.|||.|.:|:||||..||.::.:.|..::.....|
Worm   359 WIPQPALLADPRLNLFITHGGLGSTLEVAYAGKPSLMIPIFGDQMLNAKMLSRHGGAISYDKYEL 423

  Fly   422 EE-QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPL-VHM 484
            |. :...|.:.|.:||.:|..|....:.:..::|:..:::::...|:..: .|..|...|. ||.
Worm   424 ENYEKLTETVKEAISNKEYNKKALLLAEILHNQPIDPKQNLLKHAEFTAK-FGRVHALEPYSVHY 487

  Fly   485 SFIAANNIDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKK 526
            :||....:|.||:|.:..:.::.:|.|:::|:|||||...:|
Worm   488 NFIKYYMLDAYAIIIIFFLSILYVLNLIIKFVYRKIFKSKRK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	142/523 (27%)
ugt-2	NP_505672.2	egt	15..498	CDD:223071	141/521 (27%)
ugt-2	NP_505672.2	UDPGT	31..530	CDD:278624	148/534 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960