DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-49

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	147/571 - (25%)
Similarity:	238/571 - (41%)	Gaps:	98/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTV-ITVLKPVVNH--- 67
            ::|||:     |.......||....|:|.||||.....|..|.:.||:|.: ||..:|:...
Worm     5 LFLLLS-----LLAVDAGKILVYSPSISRSHLISNGRIADALVDAGHDVVMFITEYEPLTEFTGT 64

  Fly    68 KNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDD---RVRD 129
            |...||.:.....:..:..|.||        ..:||..|:......||:|......||   |..:
Worm    65 KKAKVITMKGFSTKFAEDMDGIG--------EYLLSSSRLSFLERLMFEKTCTGACDDLMTRREE 121

  Fly   130 LYLNRDNKFDLVLS------GYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVP 188
            |...|...||:..|      |..: |..||....     :.::|.|....::..:|.|...:|||
Worm   122 LEQLRAYNFDVAFSEQIDLCGVGI-VRYLGIKNH-----LWISTTPIMDAVSYNLGIPAPSSYVP 180

  Fly   189 SISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDD----------PNMPEY 243
            :|.:: :.|..|.|.||    :.:.:..|...:..|         :|.|          |:.|..
Worm   181 TIEEN-DNGDKMDFWQR----TFNLYMKIGSILIHR---------YGTDGTTEVFRKYIPDFPNV 231

  Fly   244 SELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLG 308
            .|:..|:||.|..|....:.| ||.:..||.:||:.:.....||.:.....:....:|.:::|||
Worm   232 REIAANSSLCFVNSDEVLDLP-RPTITKAIYVGGLGIPKVSKPLDKKFTNIMSKGKEGVVIISLG 295

  Fly   309 SNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEK-----TPGKSD-----------NIFYSKW 357
            |           ::...::.:..|:.|:...:::..     ...|.|           |:..::|
Worm   296 S-----------IIPFGDLPAAAKEGVLRAIQEISDYHFLIKIAKGDNNTKKLVEGIKNVDVAEW 349

  Fly   358 LPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLE 422
            |||.|||:||.:|||:.|.|..|:.|......|.:.:|||.||..|..::.|:|.|.....|.:.
Worm   350 LPQVDILSHPRLKLFVMHGGINGLVETAIQAVPTVIVPVFADQFRNGRMVEKRGIGKVLLKLDIG 414

  Fly   423 EQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFI 487
            .:.||..:|.:|:.|.|.........:.||:|.|..|.:..||::.|.|.....|......::.|
Worm   415 YESFKNTVLTVLNTPSYKKNAIRIGKMMRDKPFSPEERLTKWTQFAIDHGVLEELHVEGSRLNTI 479

  Fly   488 AANNIDIYALIAVVLVILVLLLKLLLQFIY--------RKIFAKPKKEKKH 530
            ...|:|:   ||.||.:.|.:|.:   |||        ::..:..||.||:
Worm   480 IYYNLDV---IAFVLFVFVAVLHV---FIYAFKFLCCKKRSQSNIKKSKKN 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	132/520 (25%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	141/551 (26%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	83/327 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910