DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-17

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001122841.1	Gene:	ugt-17 / 179406	WormBaseID:	WBGene00007422	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	121/569 - (21%)
Similarity:	229/569 - (40%)	Gaps:	81/569 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVL-----KPVVNH 67
            |.::.....::...:...:|....:...||.......:.:|.:.||:||::..:     |.:|..
Worm     5 YYIIFILFSIIDYSNSYKVLVFNPAFGASHSNFLGKISDILIDAGHDVTMLIPIAMQGKKHLVGS 69

  Fly    68 KNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKD-------- 124
            |.:..|:      ...|...:|....:|...:::...:..:.....:|.||||....
Worm    70 KKVKNII------RIDQDPRSIELYKQTGAEDVLRKKIWKVESDIALFFKMAGNFSKTCGYQCQH 128

  Fly   125 --DRVRDLYLNRDNKFDL-VLSGYFMNVY----QLGFAKKVKAPVIVVATMPPNQLLNPLIGNPL 182
              .:...|...::..|:| :....|:..|    .||....:.|..::..     .::...:|.|.
Worm   129 VFQQTEILEKLKNEHFELGITESLFICGYPLFDHLGVKTIINADSVLFM-----DIVKCTLGEPS 188

  Fly   183 EIAYVPS-ISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDP---NMPEY 243
            ...:.|: ||...:|   |:..:|:...........|.      ..|..:||...:|   ....:
Worm   189 SSTFYPALISPMTDK---MTLVERIKNAIQMLIPVYFS------KMRFEEELSMIEPYYNGSKTW 244

  Fly   244 SELVKNTSL--------IFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEF--LGNA 298
            .||::|.:.        :.:||         |.:|..:.|||:|||......|:...|:  |.|.
Worm   245 EELLENVAFNMVNSNRYLDYAS---------PTLPKTVFIGGMQVKTKKQGTPKLNKEWDDLLNI 300

  Fly   299 TDGAILLSLGSNVKGSHINPDTVVKMF-NVLSKLKQ-RVIWKWEDLEKTPGKS-DNIFYSKWLPQ 360
            ....:|:|.|||...|.: ||...|.| :|.:.:.: ..|||:|....|.... .|:..:.|:||
Worm   301 RKENVLVSFGSNAFSSEM-PDEFKKSFLDVFASMPEITFIWKYEQENSTIAMHLSNVKMTTWMPQ 364

  Fly   361 DDILAHPNIKLFINHAGKGGITEAQYHGKP----MLSLPVFGDQPGNADVMVKQGFGLTQSLLSL 421
            .|:||...:.||:.|.|.|...|..|.|.|    :..:|:..|||.||.::.:.|..:.....:|
Worm   365 SDLLADNRLSLFVTHGGLGSSIELAYQGTPAVVNIFKIPLMADQPRNAHMLTRHGGAIQLDKTNL 429

  Fly   422 EE-QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMS 485
            :. |..::||..||.|..|.:.....:.:..|:|.:..|.|:...::.::......|||....::
Worm   430 DNPQMIRDAIKTILDNDSYTENARKLAQILEDQPYTPAEVVLKHCDFAVKFGVLDTLQSEGRKLN 494

  Fly   486 FIAANNIDIYALIAVVLVILVLLLKLLLQFIYR------KIFAKPKKEK 528
            .....:.||..::..:::.:|:.:.|   ::::      .||:|..|.:
Worm   495 VFQFYSYDILVVVCFLIITVVVFIVL---YVFQCIKICSTIFSKKVKNE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	113/523 (22%)
ugt-17	NP_001122841.1	egt	1..513	CDD:223071	115/537 (21%)
ugt-17	NP_001122841.1	UDPGT	22..538	CDD:278624	119/548 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910