DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-9

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504312.1	Gene:	ugt-9 / 178883	WormBaseID:	WBGene00020587	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	135/571 - (23%)
Similarity:	243/571 - (42%)	Gaps:	96/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVI----TVLK---PV 64
            |.|:::...|       .|||........||.......|.::|:.||||||.    ..||   .:
Worm     9 ILLVISLVSC-------KNILVYNPIFGYSHAKFVSQLANIIADHGHNVTVFQPFHIALKNTDGL 66

  Fly    65 VNHKNITVI------MVPLTKEESQQMSDTIGAMSKTDN---SNMILSMLRMMGQMEFMFDKMAG 120
            :.:|||.:|      ...|.|:::....|.      .|:   :|.:||...|...:...|::...
Worm    67 IKNKNIEIINYYPDHYAELLKKKTPTFPDF------WDSHLMNNPVLSSFLMPKALGGEFEQTTT 125

  Fly   121 ALKDDR--VRDLYLNRDNKFDLVLSGYF--MNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNP 181
            .|..|:  :.||   ::..||::|:..|  ...|.....:....|::....:|   :::...|.|
Worm   126 QLFQDQKILNDL---KNRNFDVLLAETFEIAGFYIADLLEIPSIPLMSAVRLP---IIDSAFGQP 184

  Fly   182 LEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDD--------P 238
            ..:.|.|.....|....|  |..||......||:.:   .|||..:      |.:|        |
Worm   185 SILGYFPQQYSKVAPEAG--FLDRLNDLYRIFFWNL---TTQRLCQ------FQNDFIQKAIGHP 238

  Fly   239 NMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGI--------QVKDTPDPLPQNMAEFL 295
             :|.:.:|||.:.:....|::..:..: |.....:.:|||        .|....:.....:||
Worm   239 -VPHWRDLVKESPIYITNSNSYLDFAV-PTTATIVHVGGITIDLEKMRHVAALTEEYENILAE-- 299

  Fly   296 GNATDGAILLSLGSNVKGSHINPDT----VVKMFNVLSKLKQRVIWKWE--DLEKTPGKSDNIFY 354
               .:..:.:|.||.:: |:..||.    ::|||..|..:  ..|||:|  |::.......|:..
Worm   300 ---RESTVFISFGSVIR-SYEMPDNFKAGIIKMFKSLPDV--TFIWKYEKDDVKFQNRLPKNVHL 358

  Fly   355 SKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLL 419
            .||:||..:||...:|||:.|.|.|...|..|.|||.|.:|:|||||.|||::.:.|..:.....
Worm   359 KKWVPQPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPNNADMLARHGGAVAYDKF 423

  Fly   420 SLEE-QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVI---RHHGAAHLQSP 480
            .|.: :...:.:.::::|.:|.........:...:|:..:.:::...|:.:   :|..    |.|
Worm   424 DLADGEKLTKTVRDMVTNSKYEVNAQELLKVLSKQPIDPKLNLMKHLEFAMEFPKHRS----QVP 484

  Fly   481 LVHMS-FIAANNIDIYALIAVVLVI-LVLLLKLLLQFIYRKIFA--KPKKE 527
            .::.: .||...:|:..::.:..:. |.::.|:|  .|.||:.:  |.|:|
Worm   485 AINRTGLIAHYYLDVIGVLTLASIFGLFVIFKIL--NILRKMISLRKVKRE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	124/528 (23%)
ugt-9	NP_504312.1	egt	20..462	CDD:223071	116/474 (24%)
ugt-9	NP_504312.1	UDPGT	30..532	CDD:278624	127/540 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960