DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-12

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504309.1	Gene:	ugt-12 / 178880	WormBaseID:	WBGene00020592	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	143/576 - (24%)
Similarity:	247/576 - (42%)	Gaps:	102/576 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIYLLLATAICVLGGCHGANILGVFTSL-SPSHLIIQMSTAKVLAERGHNVTV-------ITVLK 62
            |.::.|.|.:  ...|:.:.|| :|..: ..||:......|.::|:.||:||:       :..|.
Worm     4 GTFIFLLTFL--FFECYSSKIL-IFNPIFGFSHVKFISKMADIIADHGHHVTLFQPYHIALKNLD 65

  Fly    63 PVVNHKNITVI------MVPLTKEESQQMS----------DTIGAMSKTDNSNMILSMLRMMG-- 109
            .:|.:|||.::      ...|.|.|.|..|          ..|||          ..|.:::|
Worm    66 GLVKNKNIEILNYHPTHYEELLKAEPQTFSFFWDSYLVGNPVIGA----------FLMPKLLGGE 120

  Fly   110 ----QMEFMFD-KMAGALKDDRVRDLYLNRDNKFDLV------LSGYFMNVYQLGFAKKVKAPVI 163
                .||.:.| |:...||           |.|||||      |:|:::       |..:..|.|
Worm   121 FKKTAMEVLSDQKLINELK-----------DRKFDLVIAETFELTGFYL-------AHLLDVPCI 167

  Fly   164 VVATMPPNQLLNPLIGNPLEIAYVPSISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKR 228
            .:.:.....:.|...|.|..:.:||.|..:|....|  |..||......||.||......:....
Worm   168 PMMSAVRYPIFNDQFGQPSLLGHVPQIGSAVAGEAG--FYDRLNDMFRFFFMGISQEQLNKYQNY 230

  Fly   229 LYKELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGI--------QVKDTPD 285
            ..:|..|..  :|.:.:|||. |.|:..:..|......|:..|.:::|||        ||.:.|:
Worm   231 FIEEAIGRP--VPFWKDLVKQ-SPIYITNSNPYLDYAVPSTAAIVQVGGITMDLKKLKQVGELPE 292

  Fly   286 PLPQNMAEFLGNATDGAILLSLGSNVKGSHINPDT----VVKMFNVLSKLKQRVIWKWE--DLEK 344
            .....:.|     .:..:|:|.||.:: |:..|::    ::|:|..|..:  ..|||:|  |||.
Worm   293 EYENILKE-----RESTVLISFGSVIR-SYEMPESFKAGLIKVFESLPDV--TFIWKYEKDDLEF 349

  Fly   345 TPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVK 409
            ......|:...||:||..:||...:||||.|.|.|...|..|.|||.:.:|:||||..||.::.:
Worm   350 QKRLPKNVHLKKWIPQPSLLADKRVKLFITHGGLGSTMEVAYTGKPAIVVPIFGDQHHNAVMLAR 414

  Fly   410 QGFGLTQSLLSLEE-QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIR--H 471
            .|..:......|:. :.....:.|::|:.:|.:...:...:..::|:..:.:.:...::.|:  :
Worm   415 HGGAVAYDKFDLKNGEKLTAVVHEMISSTKYQENAEALQHVLFNQPIDPKMNFLNHLDFAIKFPN 479

  Fly   472 HGAAHLQSPLVH-MSFIAANNIDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKK 526
            |.|   |.|.:: :.|:|...:|:...:.|..:::..|...||:.:..|...|..|
Worm   480 HRA---QVPAINQLGFVAHYYLDVLLFLLVSSIVITYLAISLLKKVLGKCLTKKTK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	134/536 (25%)
ugt-12	NP_504309.1	MGT	28..453	CDD:273616	120/465 (26%)
ugt-12	NP_504309.1	egt	<132..514	CDD:223071	104/415 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	0.610	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	0.610	Inparanoid score	I2826
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960