DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-45

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	134/559 - (23%)
Similarity:	231/559 - (41%)	Gaps:	75/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTV---ITVLKPVVNHK 68
            ::|||  .:.....|:  .||........||:......|.:|.|.||:||.   :.|..|....:
Worm     5 VFLLL--FVLPAASCY--KILVSVPKFGFSHMQTMGKLADILVEAGHDVTFLMPVDVPIPQNGTE 65

  Fly    69 NITVIMVPLTKEESQQMSDTI--GAMSK--TDNSNM---ILSMLRMMGQMEFMFDKMAGALKDDR 126
            ...|::||.|...::.|...:  ||::.  |.::|.   |:....|:||:.:...|   .|.|::
Worm    66 LAKVVLVPTTDAINEIMGHAMKSGAVANLWTHSANSKQGIMWSTDMIGQVSYHNTK---NLIDNK 127

  Fly   127 --VRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVA---TMPPNQLLNPLIGNPLEIAY 186
              |:.:   :|.|||:.::..| :...|.|.:.:....::.|   ::....|:  ..|.|:..::
Worm   128 ALVQQM---KDEKFDIGITELF-DFSGLAFFEVIGLKNVMGAHTTSVFEGTLM--ATGAPILPSF 186

  Fly   187 VPSISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTS 251
            ||: |.:.....| |...||.....:::...|....|..:::...|.: :....|:...||.:.:
Worm   187 VPA-SQTFTDDSG-SILSRLNNLYMTYWSYQFQNKIQSFAQKALDEHY-EKGKAPKIWNLVSDIT 248

  Fly   252 LIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATD---------GAILLSL 307
            . ||.:..|                   :.|.|.|||||:.|..|.:..         ..||...
Worm   249 W-FFVNSDP-------------------IFDFPKPLPQNIVEIAGISVPEIKPVGKEWDEILSKR 293

  Fly   308 GSNVK---GSHINPDT--------VVKMFNVLSKLKQRVIWKWEDLE-KTPGKSDNIFYSKWLPQ 360
            ..||.   ||..:|.|        :|..|.....:  ..|||::|.| |.....||:...||:||
Worm   294 SKNVLVSFGSIASPTTMPEAVKKSIVDAFAAFPDV--TFIWKYDDTESKLTAHLDNVHIVKWMPQ 356

  Fly   361 DDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEE-Q 424
            :|:||...|.:|..|.|.|.:.|:.....|::.:|:||||..||.:..:.|..|....:.|.. :
Worm   357 NDLLADKRISMFWTHGGMGSLMESAQKSVPLVVVPIFGDQMRNAQIAKRHGVALIYDKMDLSNTK 421

  Fly   425 PFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAA 489
            ....|:.|:|.||:|.......:.:......|.|:.:|...|...|........|.....||:..
Worm   422 KLIGALKEVLENPEYKKSAELLARILATERFSPRQKIIDTVEMAGRFGQMPRWTSAGKEFSFLKY 486

  Fly   490 NNIDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKKEK 528
            .|:|:..:...:..:.::...||::.:..|:.....|||
Worm   487 FNLDLVIIAVFIFFLSIVSTVLLIRHLLAKLGFSGDKEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	126/518 (24%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	127/534 (24%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	125/524 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14613
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910